Nano-film and Coating for Biomedical Application Prepared by Plasma-based Technologies
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1020-GG05-02
Nano-film and Coating for Biomedical Application Prepared by Plasma-based Technologies Xuanyong Liu1,2, and Paul K Chu2 1 Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, China, People's Republic of 2 Department of Physics & Materials Science, City University of Hong Kong, Kowloon, Hong Kong
ABSTRACT Nanosized materials have been widely applied in biomedical engineering due to their unique nano-effects. In this work, nano-TiO2 coatings and ZrO2 films were prepared using plasma technologies including plasma spraying and cathodic arc plasma deposition. The microstructure the coatings and films were assessed using TEM, SEM, and AFM. Their bioactivity and biocompatibility were evaluated using simulated body fluid soaking tests and cell culturing. Films and coatings with nanostructured surfaces can be obtained using plasma spraying and cathodic arc plasma deposition. The nanostructured surfaces can endow the films and coatings excellent bioactivity and biocompatibility. The UV-illuminated and hydrogen implanted nano-TiO2 coatings and ZrO2 films can induce bone-like apatite formation on their surfaces after immersion in a simulated body fluid for a certain period of time. The nano-TiO2 coating has better cytocompatibility than the micro-TiO2 coating, and the cytocompatibility can be improved by UV-illumination and hydrogen implantation. The bioactivity of the ZrO2 thin film deteriorates after thermal treated. The size of the particles on the surface of the film is thought to be one of the key factors responsible for the bioactivity. INTRODUCTION After medical devices are implanted into the human body, interactions between the biological environment with artificial materials surfaces, onset of biological reactions, as well as particular response paths chosen by the body occur. The materials surface plays an extremely important role in the response of the biological environment to the artificial medical devices. The initial protein interactions with implant surfaces are very important, and therefore, it is clear that if the surface morphology, structure, composition, and properties are changed, cell functions are influenced. Nanoscale materials are thought to interact with some proteins more effectively than conventional materials to mediate osteoblast functions due to their similar size and altered energetics. Balasundaram et al. [1] thought nanophase materials might be an exciting successful alternative orthopedic implant materials due to their ability to mimic the dimensions of constituent components of natural bone (like proteins and hydroxyapatite). Webster, et al. [2-4] revealed that nanophase ceramics could promote osseointegration that is critical to the clinical success of orthopedic/dental implants. Osteoblast proliferation was observed to be significantly higher on nanophase alumina, titania, and hydroxyapatite (HA) in comparison with their conventional counterparts. Furthermore, compared to conventional
ceramics, synthesis of alkaline phosphatase a
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