Nano-Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy
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REVIEW
Cite as Nano-Micro Lett. (2020) 12:96 Received: 12 January 2020 Accepted: 13 March 2020 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-00434-0
Nano‑Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy Min Su1,2, Qixuan Dai1, Chuan Chen3, Yun Zeng3, Chengchao Chu1,4 *, Gang Liu1,2 * Min Su and Qixuan Dai have contributed equally to this work * Chengchao Chu, [email protected]; Gang Liu, [email protected] State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, People’s Republic of China 2 State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People’s Republic of China 1
3
4
Department of Pharmacy, Xiamen Medical College, Xiamen 361023, People’s Republic of China Xiamen Cardiovascular Hospital, Xiamen University, Xiamen 361102, People’s Republic of China
HIGHLIGHTS • Recent advances in diagnosis and treatment of thrombosis using nano-medicine are summarized in this review. • The diagnosis system based on biomarkers and imaging nanoprobes could enable the detection in early state of thrombosis. • The targeted drug delivery nanosystems serve as clinically translatable theranostics for thrombosis treatment with minor side effects.
ABSTRACT Thrombosis is a global health issue and one of the leading factors of
clinical thrombolytics suffer from a short half-life, allergic reactions, inactivation,
nano-contrast agents; (3) targeted drug delivery systems using artificial nanoparticles; (4) microenvironment responsive drug delivery systems; (5) drug delivery
PTT
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hr
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in vitro diagnostic kits using “synthetic biomarkers”; (2) in vivo imaging using
Na
advances in this area, which revealed six types of nanoparticle approaches: (1)
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no
om
te c h n olo g
b o l y ti c t h e loa (1) ding (2)
ISA
EL
diagnosis
convertible properties. Furthermore, diagnosis and treatment of thrombosis using nano-medicines have also been widely studied. This review summarizes the recent
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Irritation t
NIR
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sis bo m
in diagnosis, drug delivery, and photo/sound/magnetic-theranostics due to their
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nic
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“biomarkers”
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engineering
(b)
in v ivo
window is too narrow to provide reasonable and effective treatment. In addition, and unwanted tissue hemorrhage. Nano-medicines have gained extensive attention
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imaging
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death. However, its diagnosis has been limited to the late stages, and its therapeutic
ra p
(c)
y
g dru
naoparticles
systems using biological nanostructures; and (6) treatments with external irradiation. The investigations of nano-medicines are believed to be of great significance, and some of the advanced drug delivery systems show potential applications in clinical theranotics. KEYWORDS Th
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