Nanoemulgel for Efficient Topical Delivery of Finasteride Against Androgenic Alopecia
- PDF / 3,982,086 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 44 Downloads / 185 Views
ORIGINAL ARTICLE
Nanoemulgel for Efficient Topical Delivery of Finasteride Against Androgenic Alopecia Deepak Kumar Upadhyay 1 & Amit Sharma 1 & Navjot Kaur 1 & Ghanshyam Das Gupta 1 & Raj Kumar Narang 1 & Vineet Kumar Rai 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose This investigation was aimed to develop and evaluate lipid nanoemulsion-based gel of finasteride for topical administration, to increase drug availability into the skin for a long duration and to improve the in vivo potential of finasteride against alopecia. Methods Nanoemulsion was prepared by a high-speed homogenization method using Vit E oil, cholesterol, and soya lecithin, characterized, and thickened using guar gum (nanoemulgel). Nanoemulgel was evaluated for pH, viscosity, drug release, skin permeability, and in vivo efficacy against alopecia. Results and Discussion Size of the drug-loaded nanoemulsion droplets was observed to be 195.20 ± 9.43 nm with uniform size distribution (PDI; 0.25 ± 0.08) and negative zeta potential (− 7.61 ± 1.35 mV). The pH 5.37 ± 0.74 of the developed gel was found to be near to the skin pH. Gel showed slow release (94.77% in 24 h) and restricted permeation through the skin, i.e., 30.7% in 24 h. Macroscopic examination showed improved hair growth in the case of nanoemulgel. Hair diameter and length were observed to be increased significantly in the case of gel as compared with the testosterone treated group. The histological investigation supports the result of macroscopic examination where nanoemulgel restored the conditions (short length hair, necrotic cell appearance with miniaturized follicles) created by testosterone on the skin. Moreover, the developed formulation was observed to be safe and stable for at least 90 days. Conclusion The results prove the clinical pertinence of this stable gel as it ensured longer stay over the skin, slower permeation and higher efficacy against alopecia. Keywords Nanoemulsion . Nanoemulgel . Finasteride . Alopecia . Topical . Soya lecithin
Introduction Alopecia is a kind of immune dysfunction where the hair is lost from the scalp. Androgenic alopecia (AGA) or male pattern baldness is the most common type of hair loss in human beings [1]. It is characterized by a reduction of hair growth and diameter into the frontal and temporal regions. It has become a problem of millions of young and old men and women [2]. Some of these follicular disorders involve changes in the Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12247-020-09483-9) contains supplementary material, which is available to authorized users. * Vineet Kumar Rai [email protected] 1
Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab 142001, India
protein synthesis of follicular cells. These changes occur because of dihydrotestosterone (DHT), which is a derivative of testosterone and causes changes in the synthesis of proteins (collagen specifically) in the follicular cells [3, 4]. Testosterone is an endogenous ho
Data Loading...
