Nanomedicine in Brain Diseases Principles and Application

This book provides an overview of the current applications of nanomaterials in brain diseases, and introduces several novel nanomaterials that have excellent potential in this field. During the last two decades, nanotechnology had matured significantly as

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Nanomedicine in Brain Diseases Principles and Application

Nanomedicine in Brain Diseases

Xue Xue Editor

Nanomedicine in Brain Diseases Principles and Application

Editor Xue Xue State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin, Tianjin, China

ISBN 978-981-13-8730-2 ISBN 978-981-13-8731-9 https://doi.org/10.1007/978-981-13-8731-9

(eBook)

© Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Preface

Nanotechnology had matured significantly during the last two decades as it has transitioned from benchtop science to applied technology. Understanding how the intrinsic properties of nanomaterials translate to complex biological responses is an area of intensive research. The challenge for nanomedicine is to utilize nanotechnology and develop innovative biocompatible nanomaterials that mimic tissue characteristics, cause minimal inflammation and cell loss, and have the abilities to function for a relative long period of time. Nevertheless, the application of nanomaterials to basic and clinical neuroscience is only at an early stage. This book is to overview the current strategies to use nanomaterials for brain disease and to introduce several novel nanomaterials that have excellent potentials in this field. With multiple functionalized modifications, nanomaterials are easy to traverse blood-brain barrier, and they are capable of diagnosing or treating brain diseases. Among these nanomaterials, nanozymes reduce oxidative stress via their intrinsic enzyme-like activation. Magnetic nanomaterials are vital contrast agents for MRI with their excellent magnetic orientation ability. Biomacromolecule-based nano