Nanomedicine and the Nose

Nanomedicine is defined as the application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical, and biological properties of materials at the nanometer scale. Nanomedicine has the potential

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Gürer G. Budak, Cengiz S. Ozkan, and Mihrimah Ozkan

Keywords

Nanomedicine • Nanobiomaterials • Theragnostic • Nanosensors • Tissue engineering • Artificial nose • Nanonose

Core Messages

• Nanotechnology revealed that organic structures have different physical, chemical, and biological features in macroscopic and nanometric forms. • “Nanomedicine” emerged as a new scientific area in nanotechnology and makes important conceptual changes in medical methods all over the world due to the different diagnostic and therapeutic alternatives.

• The use of nanomedicine in otorhinolaryngology is very important to meet the changing and increasing expectations of health. • Today, the main three areas of experimental and clinical studies related to nanomedicine concentrates: (a) Nanotechnology-based imaging and diagnostic methods (b) Targeting delivery systems (c) Regenerative nanomedicine

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G.G. Budak, MD, PhD, EMBA (*) NanoMedicine and Advanced Technologies Research Center, Gazi Teknopark C Blok, Z Kat, No: 26, Golbasi, Ankara 06830, Turkey e-mail: [email protected] C.S. Ozkan, BS, MS, PhD • M. Ozkan, BS, MS, PhD Mechanical Engineering and Bioengineering, Bourns College of Engineering, University of California Riverside, Riverside, CA, USA e-mail: [email protected]; [email protected]

Introduction

Developments in nanotechnology have revealed that macroscopic and nanometric forms of organic structures possess different features in physical, chemical, and biological aspects. By proving that nanodevices which are produced at the laboratory can interact with biomolecules, both physiological processes in healthy tissues and physiopathologic basis of diseases began to be understood in a more clear way. “Nanomedicine” which appeared as a new scientific interest parallel to the above-mentioned

T.M. Önerci (ed.), Nasal Physiology and Pathophysiology of Nasal Disorders, DOI 10.1007/978-3-642-37250-6_39, © Springer-Verlag Berlin Heidelberg 2013

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developments in nanotechnology became one of the most studied topics in the world by the reason of the fact that it leads conceptual changes in accepted and applied medical methods up to now and presents different diagnosis-treatment alternatives. Although nanotechnology is a commonly studied field all around the world, there is still no clear consensus about what nanoscala really is. One nanometer is calculated as one billionth (10−9). It is possible to fit 5 carbon atoms in this scale as in three-dimensional forms. According to BSI (PAS 71) applications, less than 100 nm or even smaller scales are evaluated within the concept of nanotechnology. While at the beginning of 2000s, studies less than 200 nm and in smaller scale were considered as nanomedicine, today this range is accepted between 5 and100 nm. Otorhinolaryngology is one of the basic disciplines of medicine which closely follows and implements medical innovations and advancements. In this regard, otorhinolaryngology is one of the leading areas which heavily utilizes microscopic and end