Neurorheumatology A Comprehenisve Guide to Immune Mediated Disorders
This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune
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Neurorheumatology A Comprehenisve Guide to Immune Mediated Disorders of the Nervous System
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Neurorheumatology
Tracey A. Cho • Shamik Bhattacharyya Simon Helfgott Editors
Neurorheumatology A Comprehenisve Guide to Immune Mediated Disorders of the Nervous System
Editors Tracey A. Cho Division of Neuroimmunology University of Iowa Iowa City, IA USA Simon Helfgott Division of Rheumatology Brigham and Women’s Hospital Harvard Medical School Boston, MA USA
Shamik Bhattacharyya Department of Neurology Brigham and Women’s Hospital Harvard Medical School Boston, MA USA
ISBN 978-3-030-16927-5 ISBN 978-3-030-16928-2 (eBook) https://doi.org/10.1007/978-3-030-16928-2 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
The pinnacle of diagnostic and therapeutic difficulty is found in medical diseases that involve multiple systems. When master clinicians roamed the wards, they were sought after to identify subacute bacterial endocarditis, vasculitis, the distant effects of cancer or rheumatologic disorders, and multisystem diseases typified by sarcoidosis, all of which eluded even the specialist. The broad intellectual power required to tackle these cases was represented by William Osler and his acolytes; for example, Philip Tumulty at Hopkins who authored The Effective Clinician, the last section of which was simply a series of transcribed notes of his rounds on just such cases. One would think that the plethora of laboratory investigations available to the modern clinician would have made these skills obsolete but they continue to be found in the two most demanding medical specialties: neurology and rheumatology. Through the agencies of the T-c
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