Neurotrophic Factors
This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett
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Gary R. Lewin Bruce D. Carter Editors
Neurotrophic Factors
Handbook of Experimental Pharmacology Volume 220 Editor-in-Chief W. Rosenthal, Berlin Editorial Board J.E. Barrett, Philadelphia J. Buckingham, Uxbridge V. Flockerzi, Homburg P. Geppetti, Florence F.B. Hofmann, Mu¨nchen M.C. Michel, Ingelheim P. Moore, Singapore C.P. Page, London
For further volumes: http://www.springer.com/series/164
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Gary R. Lewin • Bruce D. Carter Editors
Neurotrophic Factors
Editors Gary R. Lewin Department of Neuroscience Max-Delbru¨ck-Center for Molecular Medicine Berlin Germany
Bruce D. Carter Department of Biochemistry Vanderbilt University School of Medicine Nashville Tennessee USA
ISSN 0171-2004 ISSN 1865-0325 (electronic) ISBN 978-3-642-45105-8 ISBN 978-3-642-45106-5 (eBook) DOI 10.1007/978-3-642-45106-5 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2014933801 # Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Neurotrophic factors can be broadly understood as any secreted factor that has nourishing or sustaining effect on neurons. The archetypical neurotrophic factor is nerve growth factor (NGF) which was first discovered in series of elegant embryological and b
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