Non-invasive monitoring of blood gas-induced changes of myocardial oxygenation using oxygen-sensitive CMR
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POSTER PRESENTATION
Open Access
Non-invasive monitoring of blood gas-induced changes of myocardial oxygenation using oxygen-sensitive CMR Dominik P Guensch*, Kady Fischer, Jacqueline Flewitt, Janelle Yu, Ryan Lukic, Julian A Friedrich, Matthias G Friedrich From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Summary BOLD-CMR was used to assess changes in myocardial oxygenation after volunteers performed controlled hyperventilation or breath holding. Signal intensity after hyperventilation decreased whereas an increase occurred after a breath hold demonstrating that controlled breathing techniques could alter myocardial oxygenation and be identified by BOLD-CMR in healthy volunteers. Background Systemic changes of blood gases (CO2, O2) affect haemoglobin (Hb) saturation. Blood Oxygen Level-Dependent (BOLD-) CMR can be used to monitor changes of myocardial oxygenation. We hypothesized that oxygensensitive CMR detects changes in myocardial tissue oxygenation induced by hyperventilation and apnea. Methods A group of 7 healthy volunteers were instructed to hyperventilate for 1 and 2 minutes followed by a long free breath hold. A second group of 5 aquatic athletes performed a 60s breath hold and a free maximal breath hold. BOLD-sensitive SSFP cines were acquired during breath holds as well as before and after hyperventilation. Changes in signal intensity over the procedures were expressed as % change of the baseline. Capillary blood gases were measured prior to and after the procedures. Results Voluntary breath holds of athletes were significantly longer (105±38s) than those of other volunteers (38 ±12s). Breath holds lead to a significant increase in
signal intensity (*p
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