2132 Assessment of myocardial oxygenation in the canine heart using blood oxygen level-dependent magnetic resonance imag
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Meeting abstract
2132 Assessment of myocardial oxygenation in the canine heart using blood oxygen level-dependent magnetic resonance imaging Matthias Voehringer*1, Jordin D Green2, Jacqueline A Flewitt1, Cheryl A Meek1 and Matthias G Friedrich1 Address: 1Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada and 2Siemens Medical Solutions, Canada, Calgary, AB, Canada * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A401
doi:10.1186/1532-429X-10-S1-A401
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A401 © 2008 Voehringer et al; licensee BioMed Central Ltd.
Introduction Blood Oxygen Level-Dependent Magnetic Resonance Imaging (BOLD-MRI) has been used to assess myocardial oxygenation but implementation in clinical application has suffered from long scan times and inconsistent image quality. Steady-state free precession (SSFP) based sequences have been shown to have BOLD sensitivity. In addition they tend to have fewer artifacts.
Purpose To test whether a new SSFP-based sequence is robust and has sufficient diagnostic accuracy for detecting changes in myocardial oxygenation induced by endotheliumdependent and endothelium-independent coronary flow changes in the canine heart.
Methods A T2-prepared SSFP sequence with T2- and T2*-sensitivity was developed. Three anesthetized dogs were instrumented with a coronary infusion catheter in the circumflex coronary artery (LCX), an MR compatible epivascular flow probe around the LCX and a catheter in the coronary sinus. Using a clinical 1.5 T MRI system (Avanto, Siemens Medical Solutions, Germany), BOLD-sensitive imaging with the new sequence and additional T2* mapping were performed during LCX intracoronary infusion of adenosine and acetylcholine (ACh). The perfusion territory of the LCX was identified by intracoronary injection of a small Gd-DTPA bolus. Images were analyzed using validated
software. Paired T-tests were used to compare results before and after intracoronary infusion. Correlations of BOLD signal intensity and T2* values in the LCX territory with coronary venous oxygen saturation (SaO2) were calculated by linear regression analysis (SPSS13).
Results Good image quality was achieved in all dogs with excellent reproducibility of signal intensity during 20 baseline scans (SD 1.1%). In one dog ACh infusion led to a flow decrease in the LCX most likely representing a paradoxical coronary vasospastic reaction. These data were not included in the calculations for ACh effects but were included in the regression analysis. Compared to baseline and rest myocardium, there was a significant signal increase in the LC
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