Non-significant Effects of The Geometric Shape of Autologous Cartilage Grafts on Tissue Healing: An Animal Study
- PDF / 2,663,363 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 16 Downloads / 178 Views
ORIGINAL ARTICLE
BASIC SCIENCE/EXPERIMENTAL
Non-significant Effects of The Geometric Shape of Autologous Cartilage Grafts on Tissue Healing: An Animal Study Savas¸ Serel1 • Cem C ¸ erkez1 • Servet Elc¸in Is¸ ılgan Alpat1 • Polat Yig˘it1 2 • Belgin Can Hilal Go¨ktu¨rk3
•
Received: 27 March 2020 / Accepted: 26 July 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2020
Abstract Background The reconstruction of cartilage defects for cosmetic and/or functional reasons has become routine in plastic and reconstructive surgery. However, it remains challenging due to the slow turnover and low viability of cartilage grafts. Although autologous grafts can be used to determine the shape of the defect in cartilage-reconstruction surgeries, the effect of defect shape on cartilage healing has not been reported. Here, we present the first study aiming to investigate the influence of cartilage graft geometry on healing. Methods Twelve New Zealand white rabbits were used in the study. Square-, rectangle-, sphere-, and fusiformshaped cartilage defects were applied to both ears with 1-cm2 geometric templates that completely elevated the cartilage tissue without damaging the opposite perichondrium. As a control, the removed cartilage was sutured back to the right ear, whereas the left ear was sutured back without any graft. Histological examinations were made on samples taken during surgery and those taken four months
This manuscript was present as an oral presentation at EURAPS Research Council, May 25-26, 2016, Brussels-Belgium, and published as EPSRC 2016 Abstract Supplement on PRS Global Open 2016. & Savas¸ Serel [email protected] 1
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical Faculty of Ankara University, Dikimevi, 06590 Ankara, Turkey
2
Department of Histology, Embryology, Medical Faculty of Ankara University, Ankara, Turkey
3
Department of Histology, Embryology, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey
post-surgery. Chondrocyte production and organisation, chondrocyte vacuolisation, collagen synthesis, proteoglycan levels, vascularisation, focal bleeding, and peripheral proliferation were scored independently by two histologists. Results There was no statistically significant difference in the growth rates of either the control or experimental cartilage tissues when compared with that of the initial cartilage tissue (p = 0.083). Histologic comparisons revealed better outcomes in the grafted cartilage groups compared to those receiving the donor cartilage, but this was not statistically significant. Conclusions This study demonstrates that the geometric shape of the defect has no significant effect on cartilage healing. Level of Evidence This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. Keywords Cartilage
Data Loading...
