Effect of two different delivery systems of honey on the healing of oral ulcer in an animal model
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ORIGINAL ARTICLE
Effect of two different delivery systems of honey on the healing of oral ulcer in an animal model Rita Khounganian1 • Sayed Auda2,3 • Rana Al-Zaqzouq4 • Reem Al-Zaqzouq5 Hadeel Al-Semari6 • Faiyaz Shakeel2
•
Revised: 7 April 2020 / Accepted: 15 April 2020 Ó Association of Food Scientists & Technologists (India) 2020
Abstract Honey had several healing properties which includes antibacterial, anti-inflammatory and antioxidant properties. Hence, the aim of this study was to evaluate the effect of two different systems of honey on the healing of experimentally created traumatic oral ulcers in rats. Traumatic ulcers were created on the lower labial mucosa on male rats using 50% acetic acid. The rats were subsequently divided into three groups; in group one and two, the ulcers were treated with honey gel and honey adhesive respectively, whereas the third group received no treatment. The ulcers were macroscopically and microscopically studied. A statistical significant difference was observed in macroscopic investigation among the three groups in the 3rd and 7th day (p \ 0.05). However, there were no statistical significant findings by the 15th day although a complete clinical healing was virtually observed in most of the cases. Histological examination shows a Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13197-020-04459-6) contains supplementary material, which is available to authorized users. & Faiyaz Shakeel [email protected] 1
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia
2
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
3
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Asyuˆt, Egypt
4
Saudi Board Resident in Pediatric Dentistry, Riyadh, Saudi Arabia
5
Saudi Board Resident in Orthodontics, Riyadh, Saudi Arabia
6
GP Dentist, Riyadh, Saudi Arabia
statistical significant difference within each of the three groups over time (p \ 0.05). On the other hand, the mean rank values for the honey gel group were significantly higher in comparison to the other groups over time (p \ 0.05). The therapeutic value of honey gel appears to be more effective than the mucoadhesive form in shortening the duration of wound healing. Keywords Oral mucosal ulcer Wound healing Honey Mucoadhesive film
Introduction Honey is a sweet, viscous and natural liquid which is produced by honeybees after the absorption of the nectar from the flowers (Czipa et al. 2019). In many ancient cultures, it is used as a food and even as a natural remedy for several diseases (Ismail et al. 2015). Honey is obtained from several natural sources but its main biological source is Apis mellifera (honeybee) (Czipa et al. 2019; Selvaraju et al. 2019). Honey’s healing properties have been endorsed across ancient cultures and by the most influential religions. However, from the late nineteenth century until present, it had
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