Norfloxacin
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Fixed drug eruptions: case report A 63-year-old woman developed fixed drug eruptions during treatment with norfloxacin for cystitis [dosage not stated]. The woman presented to the emergency department with multiple tender erythematous-violaceous oval plaques on the neck that were around 3–6cm in size and progressed within 48 hours. Additionally, she reported the development of fever, malaise and polyarthralgia at the same time. During anamnesis, it was noted that she had recently completed a 1 week course of an unspecified oral antibiotic due to cystitis. The course was completed 1 week prior to the admission. No known allergies or ongoing medications were reported. No abnormalities were noted on blood biochemistry tests or haemogram, and a provisional diagnosis of fixed drug eruption was considered. The woman received treatment with prednisolone, and all the complaints resolved except residual hyperpigmentation. She was suggested to clarify the name of the antibiotic and not to receive it in future. However, 3 months after the initial presentation, she returned with identical complaints. She reported taking the same antibiotic, 2 days previously, which she now identified as norfloxacin. Her treatment was started with prednisolone with complete resolution of the fixed drug eruption. Based on the redevelopment of fixed drug eruption after repeat exposure to the oral drug (considered as an unintentional oral challenge test), a diagnosis of fixed drug eruption secondary to norfloxacin was confirmed. After 3 months, patch tests were performed, which showed positive results with norfloxacin as well as for ciprofloxacin. Thus, cross-reactivity to ciprofloxacin was identified, and she was recommended to avoid quinolones in future. Alpalhao M, et al. Fixed drug eruption due to norfloxacin with cross-reactivity to ciprofloxacin: A case report. Contact Dermatitis 83: 135-137, No. 2, 03 Apr 2020. Available from: URL: http://doi.org/10.1111/cod.13544 803497256
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Reactions 22 Aug 2020 No. 1818
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