Carbon dots-incorporated pH-responsive agarose-PVA hydrogel nanocomposites for the controlled release of norfloxacin dru
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Carbon dots‑incorporated pH‑responsive agarose‑PVA hydrogel nanocomposites for the controlled release of norfloxacin drug Pranjali Date1 · Archana Tanwar1,2 · Priyanka Ladage1 · Kisan M. Kodam1 · Divya Ottoor1 Received: 10 July 2019 / Revised: 10 September 2019 / Accepted: 3 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Several hydrogels-based delivery systems are designed and studied in order to meet the requirements in biomedical fields. Herein, the possibility of carbon dots (CDs)incorporated hydrogel nanocomposites was investigated for the drug release study. Highly fluorescent CDs synthesized from groundnuts using hydrothermal method were characterized with TEM, FTIR, UV–visible and fluorescence spectroscopy. pH-responsive biodegradable hydrogel nanocomposites were synthesized using agarose polymer and agarose–poly(vinyl alcohol) copolymer with the successful integration of CDs. CDs improved the swelling as well as the biodegradation properties of the prepared hydrogel nanocomposites. Structural changes of prepared hydrogel nanocomposites have been characterized using FTIR, SEM and TGA analysis. Hydrogel nanocomposites showed highly porous surface as shown by SEM analysis. In this study, norfloxacin (NFX) was used as a model drug to investigate the in vitro release behavior at two different pH (pH 1.2 and pH 7.4). NFX release from hydrogel nanocomposites followed zero-order kinetics, and Korsemeyer–Peppas model confirmed the release of NFX through erosion of hydrogel nanocomposites. Degradation of hydrogel nanocomposites films was checked using hen egg lysozyme enzyme which confirmed the biodegradable nature of prepared hydrogel nanocomposites films. MTT assay confirmed the nontoxic nature of hydrogel nanocomposites films when treated with blood cells (PBMC).
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s0028 9-019-03015-3) contains supplementary material, which is available to authorized users. * Divya Ottoor [email protected] 1
Department of Chemistry, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411 007, India
2
Department of Chemistry, Fergusson College (Autonomous), F.C. Road, Pune 411 004, India
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Polymer Bulletin
Graphic abstract
Cross linked hydrogel CDs
NFX pH-7.4
pH-1.2
pH-1.2
pH-7.4
Hydrogelnanocomposites
pH responsive swelling nature of hydrogel nanocomposites
(a)
(b)
In vitro drug release behavior of NFX from hydrogelnanocomposites
Surface morphology of (a) AC and (b) APC
Keywords Agarose · Poly(vinyl alcohol) · Hydrogel · Controlled drug delivery · Norfloxacin (NFX) · Carbon dots
Introduction Hydrogel nanocomposites are a class of advanced nanomaterials that have found profound uses in biomedical and pharmaceutical fields. Nanocomposites generally exhibit improved mechanical strength, thermal conductivity and toughness due to the integration of nano-sized particles inside their matrix. Several unique properties of hydrogel nanocomposites, s
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