Nucleic Acid Polymerases
This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independen
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Katsuhiko S. Murakami Michael A. Trakselis Editors
Nucleic Acid Polymerases
Nucleic Acids and Molecular Biology
Volume 30
Series Editor Janusz M. Bujnicki International Institute of Molecular and Cell Biology Laboratory of Bioinformatics and Protein Engineering Trojdena 4 02-109 Warsaw Poland
For further volumes: http://www.springer.com/series/881
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Katsuhiko S. Murakami • Michael A. Trakselis Editors
Nucleic Acid Polymerases
Editors Katsuhiko S. Murakami Dept. of Biochem. and Mol. Biology The Pennsylvania State University University Park Pennsylvania USA
Michael A. Trakselis Department of Chemistry University of Pittsburgh Pittsburgh Pennsylvania USA
ISSN 0933-1891 ISSN 1869-2486 (electronic) ISBN 978-3-642-39795-0 ISBN 978-3-642-39796-7 (eBook) DOI 10.1007/978-3-642-39796-7 Springer Heidelberg New York Dordrecht London © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
More than any other class of enzymes, nucleic acid polymerases are directly responsible for an overabundance of enzymatic, regulatory, and maintenance activities in the cell. DNA polymerases accurately replicate copies of genomes in all forms of life as well as have specialized roles in DNA repair and immune respon
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