Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma?
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COUGH AND ASTHMA
Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma? Shoaib Faruqi1 · Dominic L. Sykes1 · Michael G. Crooks1 · Kayleigh Brindle1 · Joanne Thompson1 · Alyn H. Morice1 Received: 29 June 2020 / Accepted: 27 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Cough is an important symptom of asthma. The objective assessment of chronic cough has been enhanced by the development of ambulatory cough monitoring systems. Mepolizumab has been demonstrated to reduce exacerbations in eosinophilic asthmatics long-term. We evaluate the utility of objective cough count as an outcome measure in severe eosinophilic asthma treated with mepolizumab. Consecutive, consenting patients initiated on treatment with mepolizumab had a 24-h cough count recorded at baseline; this was repeated at 1, 3 and 6 months. Asthma control questionnaire (ACQ) scores and exacerbation frequency were also recorded. The mean 24-h cough count in 11 subjects (8 females, mean age 53.6 years) was 172.4 at baseline; at 1, 3 and 6 months following initiation of treatment this decreased to 101.4, 92 and 70.8, respectively (p
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