Oncothermia: Principles and Practices
Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless,
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Andras Szasz · Nora Szasz · Oliver Szasz
Oncothermia: Principles and Practices
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Andras Szasz Department of Biotechnics Faculty of Engineering St. Istvan University Pater K. u. 1 2103 Godollo Hungary [email protected]
Nora Szasz McKinsey & Co. Park Plaza 75 02116 Boston MA, USA [email protected]
Oliver Szasz Oncotherm Inc. Ibolya u. 2 2071 Paty Hungary [email protected]
ISBN 978-90-481-9497-1 e-ISBN 978-90-481-9498-8 DOI 10.1007/978-90-481-9498-8 Springer Dordrecht Heidelberg London New York © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 Oncology – Treatments and Their Limits . . . . . . . . . 1.1 Cancer – Short History and Efforts to Cure . . . . . . 1.1.1 Historical Notes . . . . . . . . . . . . . . . 1.1.2 The “War” Against Cancer . . . . . . . . . . 1.2 Paradigm and Challenges of Oncotherapies . . . . . . 1.3 Limitations of Oncotherapies – The Quest for a Step Forward . . . . . . . . . . . . . . . . . . . . . . . . 1.3.1 Medical Challenge of Oncotherapies . . . . . 1.3.2 Ethical Challenge of Oncotherapies . . . . . 1.3.3 The Challenge of Evaluating the Results . . .
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2 Hyperthermia Results and Challenges . . . . . . . . . . . . . . 2.1 Hyperthermia Approach . . . . . . . . . . . . . . . . . . . 2.1.1 Definition of Hyperthermia in Oncology . . . . . . 2.1.2 Basic Concepts of Oncological Hyperthermia . . . 2.1.3 Technical Variations of Hyperthermia in Oncology 2.2 Effects of Hyperthermia . . . . . . . . . . . . . . . . . . . 2.2.1 Higher Baseline Temperature . . . . . . . . . . . 2.2.2 Vascular Changes . . . . . . . . . . . . . . . . . . 2.2.3 Cellular Membrane Changes . . . . . . . . . . . . 2.2.4 Lactic Acid Formation . . . . . . . . . . . . . . . 2.2.5 ATP Depletion . . . . . . . . . . . . . . . . . . . 2.2.6 Altered DNA Replication . . . . . . . . . . . . . . 2.2.7 Enhanced Immune Reaction . . . . . . . . . . . . 2.2.8 Pain Reduction . . . . . . . . . . . . . . . . . . . 2.2.9 Selective Gain of the Heat Resistance . . . . . . . 2.3 Clinical Oncological Hyperthermia . . . . . . . . . . . . . 2.3.1 Local and Whole-Body Heating . . . . . . . . . . 2.3.2 Hyperthermia as a Complementary Method . . . . 2.4 Hyperthermia Successes . . . . . . . . . . . . . . . . . . . 2.4.1 Brain Tumor Treatment by Hyperthermia . . . . . 2.4.2 Pancreas Tumor Treatment by Hyperthermia . . . 2.4.3 Lung and Bronchus . . . . . . . . . . . . . . . . .
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