Oral Health and the Altered Colonic Mucosa-Associated Gut Microbiota
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ORIGINAL ARTICLE
Oral Health and the Altered Colonic Mucosa‑Associated Gut Microbiota Anthony A. Xu1 · Kristi Hoffman2 · Shawn Gurwara1 · Donna L. White1,4,5,6,7 · Fasiha Kanwal1,3,4,5,6 · Hashem B. El‑Serag1,3,4,5,6 · Joseph F. Petrosino2,4,5 · Li Jiao1,3,4,5,6,7 Received: 14 May 2020 / Accepted: 10 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Systemic diseases have been associated with oral health and gut microbiota. We examined the association between oral health and the community composition and structure of the adherent colonic gut microbiota. Methods We obtained 197 snap-frozen colonic biopsies from 62 colonoscopy-confirmed polyp-free individuals. Microbial DNA was sequenced for the 16S rRNA V4 region using the Illumina MiSeq, and the sequences were assigned to the operational taxonomic unit based on SILVA. We used a questionnaire to ascertain tooth loss, gum disease, and lifestyle factors. We compared biodiversity and relative abundance of bacterial taxa based on the amount of tooth loss and the presence of gum disease. The multivariable negative binomial regression model for panel data was used to estimate the association between the bacterial count and oral health. False discovery rate-adjusted P value (q value)
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