Osteoarthritis Pathogenesis, Diagnosis, Available Treatments, Drug S

This comprehensive book grants readers exclusive insight into current advancements in the field of osteoarthritis (OA). Contributions from leading scientists and clinicians provide a detailed introduction into current understanding of the pathogenesis of

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Osteoarthritis Pathogenesis, Diagnosis, Available Treatments, Drug Safety, Regenerative and Precision Medicine

Osteoarthritis

Mohit Kapoor • Nizar N. Mahomed Editors

Osteoarthritis Pathogenesis, Diagnosis, Available Treatments, Drug Safety, Regenerative and Precision Medicine

Adis

Editors Mohit Kapoor Division of Genetics and Development Toronto Western Research Institute University Health Network and Department of Surgery University of Toronto Toronto, Ontario Canada

Nizar N. Mahomed Division of Orthopaedics Toronto Western Hospital Toronto, Ontario Canada

ISBN 978-3-319-19559-9 ISBN 978-3-319-19560-5 DOI 10.1007/978-3-319-19560-5

(eBook)

Library of Congress Control Number: 2015945968 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Adis is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Preface

Designed as a comprehensive resource, this book is a collaborative effort by leading clinicians and scientists in the field of osteoarthritis. This book consists of 13 chapters that explore the destruction of joints such as the knee, hip, shoulder, elbow, ankle, hand, wrist, and spine. Through the analysis of imaging modalities, joint conservation techniques, biomarkers, treatment options, and safety profiles of available treatments, this book aims to present the most current and cutting-edge research in the field of osteoarthritis. Finally, this book goes beyond to introduce regenerative approaches for treatment and the need for precision medicine in osteoarthritis. The production of this book has been an enjoyable experience, and we would like to thank the authors and everybody involved in creating this book. Toronto, ON, Canada

Mohit Kapoor Nizar N. Mahomed

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Acknowledgement

The editors would like to thank each contributor of this book for their treme