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0950-D04-20

Osteoblast Response to Amino Acid-Modified Surfaces Simon Todd, Rachel Rawsterne, Rein Ulijn, and Julie Gough Materials Science, University of Manchester, Grosvenor Street, Manchester, M1 7HS, United Kingdom

ABSTRACT The behavior of cells at the material surface is of critical importance in the design of biomaterials. To understand and control cell responses to surfaces, different surface chemistries are commonly compared. In this study we exploit the chemical diversity of the 20 naturally occurring amino acids to make 20 surfaces with different chemical properties. The biological response of osteoblasts to these surfaces was examined. The osteoblast response to the surfaces was found to be dependant on the wettability of the surface with polar amino acid surfaces (Cys

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