Oxidative stress markers in the follicular fluid of patients with polycystic ovary syndrome correlate with a decrease in
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REPRODUCTIVE PHYSIOLOGY AND DISEASE
Oxidative stress markers in the follicular fluid of patients with polycystic ovary syndrome correlate with a decrease in embryo quality Yue Liu 1,2,3,4,5 & Zhiheng Yu 1,2,3,4,5 & Shigang Zhao 1,2,3,4,5 & Lei Cheng 1,2,3,4,5 & Yuanyuan Man 1,2,3,4,5 & Xueying Gao 1,2,3,4,5 & Han Zhao 1,2,3,4,5,6 Received: 13 July 2020 / Accepted: 2 November 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Elevated oxidative stress has been proposed as an important factor in the pathogenesis of polycystic ovary syndrome (PCOS)-related infertility. Our study was aimed at simultaneously exploring local and systemic oxidative stress in PCOS individuals and its relationship with embryo quality. Methods We recruited 86 PCOS cases and 60 controls. Five representative oxidative stress markers, namely, total oxidant capacity (TOC), total antioxidant capacity (TAC), malonaldehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD), were measured in both follicular fluid (FF) and serum. Results Women with PCOS compared to normal controls had higher levels of TOC in both FF (10.13 ± 2.68 vs.7.03 ± 2.45, P < 0.001) and serum (11.76 ± 2.92 vs. 8.82 ± 2.57, P < 0.001). The oxidative stress index (OSI, the ratio of TOC to TAC) was also higher in PCOS cases. They were still significant after BMI adjustment (Padj
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