Paracetamol overdose
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Paracetamol overdose Nausea following misuse and toxicity: case report
A 54-year-old man developed nausea secondary to drug toxicity following misuse of paracetamol in an overdose. The man, who had a history of psychiatric disease received hundred rectal 500mg paracetamol suppositories i.e. dose of 50g, over a period of 2.5 hours in order to reduce anxiety (misuse and overdose). After 7 hours, he presented to hospital with nausea and anxiety [outcome not stated]. Investigations revealed blood paracetamol concentration of 1094 mumol/L. After 11 hours, the concentration level peaked to 1292 mumol/L (drug toxicity), and at 19 hours it was 149 mumol/L. Eleven hours after the overdose, the man was initiated on acetylcysteine [N-acetylcysteine] infusion and enema. He was discharged after 2 days. Grass JN, et al. Rectal overdose of paracetamol. Clinical Toxicology 58: 615, No. 6, 2020. Available from: URL: http://doi.org/10.1080/15563650.2020.1741981 [abstract]
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Reactions 26 Sep 2020 No. 1823
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