Pericytes Relationship with Cancer Stem Cells in the Colon
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PERICYTES (A BIRBRAIR, SECTION EDITOR)
Pericytes Relationship with Cancer Stem Cells in the Colon Elsa N. Garza Treviño 1
&
Paulina Delgado-Gonzalez 1 & Carlos I. Valencia Salgado 1 & Jorge L. Ortega Garcia 1
Accepted: 14 October 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose of Review Stand out contribution of pericytes and cancer stem cells (CSC) to progression of colorectal cancer (CRC). Recent Findings Reported that CSC are responsible for the initiation and spread of the tumor; however, the microenvironment in the tumor plays a decisive role in prognosis; CSC and pericytes interaction are capable of contributing to neovascularization and promoting metastasis. We reviewed the contribution of cellular communication between pericytes, endothelial cells, and CSC with focus vascular remodeling, metastasis, angiogenesis, and vasculogenesis. Also, we were analyzed concise microRNAs and approved therapeutic target with the potential anti-angiogenic as treatment of CRC. Summary This work seeks to give an overview of pericytes in cancer and their role angiogenic with CSC in CRC. Keywords Cancer stem cells . Pericytes . Angiogenesis . Colorectal cancer . Epithelial mesenchymal transition . miRNAs in angiogenesis
Introduction Colorectal cancer (CRC) is any cancer that affects colon or rectum, it remains as a third most deadly by cancer worldwide. Actual treatment for the CRC includes surgical remove of the tumor, commonly associated with adjuvant or neo-adjuvant chemotherapy. Radiotherapy combination with surgery or chemotherapy is an option that has proven useful, but does not have a routine use in places where technical limitations are present, due to the radio-sensitivity of the rest of the bowel. This article is part of the Topical Collection on Pericytes * Elsa N. Garza Treviño [email protected] Paulina Delgado-Gonzalez [email protected] Carlos I. Valencia Salgado [email protected] Jorge L. Ortega Garcia [email protected] 1
Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autónoma de Nuevo León (UANL), Av. Francisco I. Madero y Dr. Eduardo A. Pequeño s/n., C.P. 64460 Monterrey, N.L, Mexico
Immunotherapy has been found to be useful for certain kinds of CRC, used against a wide spectrum of targets present in the malignant cells, offering a new approach of treatment. However, actual therapies for this condition are still far from being optimal. The 5-year survival rate in non-localized stages is around 60%. Metastasis and resistance treatment main cause of death. Some theories have been structured to elucidate the main causes of failure of actual treatments, many of them indicating that the previously described heterogeneity of cells that comprise a tumor. Cancer stem cells (CSCs) has the ability of self-renew and the variety of cells that can be originated from differentiation of them; this indicates that the CSCs can initiate tumor formation and generate progenies of distinct
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