PET Image Processing in the Early Diagnosis of PD
Objective To clear which degree of damage of mice dopamine could change the brain glucose metabolic activity and whether the change can be detected with positron emission tomography imaging processing and to find a positron emission tomography data proces
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PET Image Processing in the Early Diagnosis of PD Kai Ma, Zhi-an Liu, Ya-ping Nie and Dian-shuai Gao
Abstract Objective To clear which degree of damage of mice dopamine could change the brain glucose metabolic activity and whether the change can be detected with positron emission tomography imaging processing and to find a positron emission tomography data processing method effectively. Methods Using Positron Emission Tomography imaging technology to image 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine model mice, data analysis after imaging. Results The study of Parkinson’s disease glucose metabolism found that mice with bilateral striatal glucose metabolism reduced after 2 weeks 1-methyl-4-phenyl -1,2,3,6tetrahydropyridine administration. And the data processing method of Positron Emission Tomography imaging techniques is discussed in detail, Specific typical statistical parameter mapping processing of positron emission tomography data processing steps and the experimental results are given. Conclusions Positron emission tomography imaging can detect early diagnosis of Parkinson’s disease and Statistical pixel processing positron emission tomography data image processing method is an effective data image processing methods.
Keywords Parkinson’s disease Positron emission tomography transporter Glucose metabolism
Dopamine
K. Ma Y. Nie Institute of Medical Information Science, Xuzhou Medical College, Xuzhou 221004 Jiangsu, China Z. Liu D. Gao (&) Department of Basic Medical, Xuzhou Medical College, Xuzhou 221004 Jiangsu, China e-mail: [email protected]
S. Li et al. (eds.), Frontier and Future Development of Information Technology 2871 in Medicine and Education, Lecture Notes in Electrical Engineering 269, DOI: 10.1007/978-94-007-7618-0_364, Springer Science+Business Media Dordrecht 2014
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K. Ma et al.
364.1 Introduction Parkinson’s disease (PD) is a serious central nervous system degenerative diseases of elderly. The main pathological change is dopamine neuron degeneration and death in the substantia nigra pars compacta, so that the decrease in striatal dopamine (DA) content. Currently, the treatment of PD always supplement the DA and strengthen the DA role of the alternative method, but the long-term effect is not ideal. If early diagnosis of PD could be made before the death of DA neurons degeneration and give neuroprotective treatment rather than an alternative therapy [1]. It is possible to significantly delay the course of the disease and improve the patient’s quality of life [2–5]. Positron Emission Tomography (PET) is able to obtain some physiological or biochemical information of the human or animal organs or lesions, is an advanced nuclear medical imaging technique. This article study the changes in brain glucose metabolism in mice from MPTP injury DA neuron until mice appear symptoms of PD by using PET imaging technology, the main purpose is to clear which degree of damage of mice DA neuron could change the brain glucose metabolic activity and whether the change can be detected wit
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