PET/MRI Radiomics in Rectal Cancer: a Pilot Study on the Correlation Between PET- and MRI-Derived Image Features with a
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RESEARCH ARTICLE
PET/MRI Radiomics in Rectal Cancer: a Pilot Study on the Correlation Between PETand MRI-Derived Image Features with a Clinical Interpretation Barbara Juarez Amorim,1,2,3 Angel Torrado-Carvajal,2,4 Shadi A Esfahani,1 Sara S Marcos,5 Mark Vangel,1,2,6 Dan Stein,7 David Groshar,7 Onofrio A Catalano1,2,8 1
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA, 02114, USA Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 3 Division of Nuclear Medicine, State University of Campinas (UNICAMP), Campinas, Brazil 4 Medical Image Analysis and Biometry Laboratory, Universidad Rey Juan Carlos, Madrid, Spain 5 Division of Nuclear Medicine, Puerta de Hierro, University Hospital, Madrid, Spain 6 Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA 7 Department of Nuclear Medicine, Assuta Medical Centers, Tel Aviv, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 8 Department of Radiology, University of Naples “Parthenope”, Naples, Italy 2
Abstract Purpose: The aim of this study was to explore possible correlations among different imaging features from 2-deoxy-2-[18F]fluoro-D-Glucose positron emission tomography/magnetic resonance imaging (PET/MRI) in rectal cancer (RC). Procedures: RC patients who underwent PET/MRI were enrolled. A region of interest (ROI) was drawn around each primary RC on PET/MRI images (PET, pelvic axial T2w, and apparent diffusion coefficient maps (ADC)). Multiple imaging features were assessed, and Pearson’s correlation was used to explore possible correlations among them. Results: A total of 13 patients were included, mean age 56.1 years old, 6 females. A strong inverse correlation was observed between SUVpeak and ADCmean values, MTV and T2 sphericity, MTV and ADC sphericity, MTV and T2 entropy, and TLG and ADC sphericity. There was also strong direct correlation between PET entropy and ADC sphericity. Conclusions: In conclusion, several clinically relevant correlations were observed between PET and MRI imaging features. These findings show how the use of both modalities provides complementary information. Key words: Rectal cancer, Imaging features, PET/MRI, FDG
Introduction Barbara Juarez Amorim and Angel Torrado-Carvajal contributed equally to this work. Correspondence to: Onofrio Catalano; e-mail: [email protected]
Colorectal cancer is the second cancer in number of deaths and the third in incidence in both males and females worldwide [1]. In the USA, colorectal cancer was responsible for an estimated 51,020 deaths in 2019 [2]. Rectal cancer
Amorim B.J. et al.: PET/MRI Radiomics in Rectal Cancer: a Pilot Study
(RC) has experienced incredible improvements in treatment [3]. The current treatment for locally advanced rectal cancer includes neoadjuvant chemoradiotherapy, followed by total mesorectal excision and adjuvant chemotherapy. Cancer imaging is e
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