pH-Sensitive Nanocomposite Hydrogels Based on Carboxymethyl Chitosan/Poly(vinyl alcohol)/ZnO Nanoparticle with Drug Deli
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EDICAL POLYMERS
pH-Sensitive Nanocomposite Hydrogels Based on Carboxymethyl Chitosan/Poly(vinyl alcohol)/ZnO Nanoparticle with Drug Delivery Properties Iman Gholamalia,*, Manzarbanou Asnaashariisfahania, and Eskandar Alipoura aDepartment
of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, 19585/936 Iran *e-mail: [email protected] Received January 20, 2020; revised April 26, 2020; accepted April 30, 2020
Abstract—The CsMe/PVA/ZnO nanocomposite hydrogels have been introduced as a new object to deliver drugs, which is dependent on pH. They were prepared successfully in situ by forming of ZnO nanoparticles within swollen CsMe/PVA hydrogels. The resulting hydrogels were examined by running various experimental procedures such as FTIR, XRD, EDX and SEM. XRD and EDX patterns verified the formation of ZnO nanoparticles in the hydrogel networks; moreover, the formation of ZnO nanoparticles with size range from 34 to 88 nm within the hydrogel matrix was confirmed by SEM micrographs. It was shown that increased Zn2+ concentration led to increased number of Zn nanoparticles. The prepared nanocomposite hydrogels were studied in terms of the swelling behavior at the pH of 2.1 (simulated gastric fluid) and pH 7.4 (simulated intestinal fluid); the results showed that the prepared nanocomposite hydrogels outperformed the pure CsMe/PVA hydrogels in terms of swelling capacity. To study the efficiency of this new category of nanocomposite hydrogels drug release tests were conducted. For CsMe/PVA hydrogels containing ZnO nanoparticles sustained and controlled drug releases were observed that increased with increase in ZnO nanoparticles content which can lead to prolong the release of the drug. DOI: 10.1134/S0965545X20050089
INTRODUCTION Hydrogels are capable of absorbing great amounts of biological fluids or water; they are insoluble under physiological conditions in their three-dimensional structures [1] It has been argued that hydrogel compounds are beneficial for agriculture [2] and biomedical applications, including controlled drug delivery [3, 4], wound dressing [5], tissue engineering [6] because of their outstanding properties including high swelling/deswelling ratio, non-toxicity, biocompatibility, and biodegradability. In addition, they are used as antibacterial materials in biomedicine [7, 8]. Chitosan is one of the most abundant natural cationic polymers produced commercially by deacetylation of chitin. Due to its unique polycationic nature, it has been widely applied in medical and pharmaceutical fields [9, 10]. Carboxymethyl chitosan (CsMe) is a biodegradable and biocompatible polymer obtained from the reaction of chitosan with monochloroacetic acid and in an alkaline medium [11]. CsMe has several advantages over chitosan such as increased water solubility, increased antioxidant property [12] high moisture retention ability [13] and higher antibacterial activity [9, 14] that Wahid et al. prepared and characterized antibacterial CsMe/ZnO nanocomposite hydrogels by in situ formation of ZnO nanoparti
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