In-situ synthesized carboxymethyl chitosan/poly(vinyl alcohol) bio-nanocomposite hydrogels containing nanoparticles with
- PDF / 2,653,226 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 10 Downloads / 200 Views
Bull Mater Sci (2020)43:264 https://doi.org/10.1007/s12034-020-02231-2
Sadhana(0123456789().,-volV)FT3](012345 6789().,-volV)
In-situ synthesized carboxymethyl chitosan/poly(vinyl alcohol) bio-nanocomposite hydrogels containing nanoparticles with drug-delivery properties IMAN GHOLAMALI1, MANZARBANOU ASNAASHARIISFAHANI1,*, ESKANDAR ALIPOUR1 and ABBAS AKHAVAN SEPAHI2 1
Department of Chemistry, North Tehran Branch, Islamic Azad University, P.O. Box 19585/936, Tehran, Iran Department of Microbiology, Faculty of Science, North Branch, Islamic Azad University, P.O. Box 19585/936, Tehran, Iran *Author for correspondence ([email protected]) 2
MS received 7 December 2019; accepted 16 March 2020 Abstract. A drug-delivery approach was developed through effective preparation of bio-nanocomposite hydrogels in situ with ZnO/CuO/Ag nanoparticles being formed within swollen carboxymethyl chitosan (CMCh)/poly(vinyl alcohol) (PVA) hydrogels. Different experimental techniques, including Fourier transform-infrared, X-ray diffraction (XRD), energy-dispersive X-ray (EDX) analysis, and scanning electron microscopy (SEM) were applied to study and compare the prepared hydrogels. XRD and EDX analyses confirmed the formation of nanoparticles in the hydrogel matrix, while SEM micrographs showed that ZnO, CuO and Ag nanoparticles ranged from 36.26 to 76.09 nm, 34.15–71.71 nm and 36.21–78.47 nm within the same matrix, respectively. According to the results, an increased number of nanoparticles resulted from increased ion concentration. At pH 2.1 and pH 7.4, the bio-nanocomposite hydrogels were investigated in terms of the swelling behaviour; in comparison with neat CMCh/PVA hydrogel, they showed a pH-sensitive swelling ratio. As an in-vitro drug release test, the bio-nanocomposite hydrogels were applied to sustained and controlled drugdelivery system that increased with the increase in nanoparticles content that could result in protracted release of the ibuprofen. Keywords.
1.
Carboxymethyl chitosan; poly(vinyl alcohol); bio-nanocomposite hydrogel; nanoparticles; drug delivery.
Introduction
Hydrogels are three-dimensional (3D) networks, linear or branched polymers capable of absorbing significant amounts of water, saline and physiological solutions in comparison with general absorbent materials [1]. Also, because of their excellent characteristics, such as non-toxicity, biocompatibility and biodegradability, high swelling ratio hydrogels would have basic roles in agriculture [2] and biomedical applications including tissue engineering [3], wound dressing [4], and controlled drug and protein delivery [5,6]. Chitosan is a natural cationic polymer existing abundantly; commercially, chitin is deacetylated to produce chitosan [7,8]. Carboxymethyl chitosan (CMCh) is a biocompatible and biodegradable polymer; it is the result of chitosan reacting with monochloroacetic acid in an alkaline medium [9]. CMCh outperforms chitosan in terms of some features including increased antioxidant property, high moisture retention ability [10], increa
Data Loading...
