Piezoelectric bioMEMS cantilever for measurement of muscle contraction and for actuation of mechanosensitive cells
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Research Letter
Piezoelectric bioMEMS cantilever for measurement of muscle contraction and for actuation of mechanosensitive cells Elizabeth A. Coln, Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA; Department of Electrical & Computer Engineering, University of Central Florida, 4328 Scorpius St., Orlando, FL 32816, USA Alisha Colon, Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA Christopher J. Long and Narasimhan Narasimhan Sriram, Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL 32826, USA Mandy Esch and Jean-Matthieu Prot, Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY 14853, USA Daniel H. Elbrecht, Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA Ying Wang, Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY 14853, USA Max Jackson, Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL 32826, USA Michael L. Shuler, Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL 32826, USA; Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY 14853, USA James J. Hickman , Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA; Department of Electrical & Computer Engineering, University of Central Florida, 4328 Scorpius St., Orlando, FL 32816, USA; Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL 32826, USA Address all correspondence to James J. Hickman at [email protected] (Received 11 June 2019; accepted 6 September 2019)
Abstract A piezoelectric biomedical microelectromechanical system (bioMEMS) cantilever device was designed and fabricated to act as either a sensing element for muscle tissue contraction or as an actuator to apply mechanical force to cells. The sensing ability of the piezoelectric cantilevers was shown by monitoring the electrical signal generated from the piezoelectric aluminum nitride in response to the contraction of iPSC-derived cardiomyocytes cultured on the piezoelectric cantilevers. Actuation was demonstrated by applying electrical pulses to the piezoelectric cantilever and observing bending via an optical detection method. This piezoelectric cantilever device was designed to be incorporated into bodyon-a-chip systems.
Introduction Microcantilever sensors have been increasingly used in biomedical microelectromechanical systems (bioMEMS) devices to measure small scale mechanical movement and are typically silicon-based cantilevers due to availability and easy integration with silicon-based technology.[1] One application of these microcantilever sensors is in the determination of contractile force of cardiac and skeletal muscle tissues using in vitro body-on-a-chip systems.[2–7] These body-on-a-chip systems integrate b
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