Polymeric Microfluidic Devices for High Performance Optical Imaging and Detection Methods in Bioanalytics
The commercialization of miniaturized systems for bioanalytical applications demands fabrication methods which allow the generation of disposable devices which on the one hand fulfill requirements with respect to high geometrical precision and compatibili
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Abstract The commercialization of miniaturized systems for bioanalytical applications demands fabrication methods which allow the generation of disposable devices which on the one hand fulfill requirements with respect to high geometrical precision and compatibility with the chemistries involved and, on the other hand, offer manufacturing cost which allows these devices to become low-cost disposables. We present a technology chain for the realization of such devices using polymer replication methods and subsequent back-end processing steps. Due to the usual complex set of requirements faced during the development of a bioanalytical system utilizing microfluidic functionality, development strategies for their implementation will be discussed. Practical examples of devices for the use in biotechnological applications will be presented. Keywords Injection molding • Integrated device • Polymer microfabrication
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Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Development and Integration Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Importance of Optical Technologies in Microfluidics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Manufacturing Technologies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Application Example . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.1 Functional Modules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.2 Integrated Device . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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H. Becker (*) • C. G€artner microfluidic ChipShop GmbH, Stockholmer Str. 20, 07747 Jena, Germany e-mail: [email protected] W. Fritzsche and J. Popp (eds.), Optical Nano- and Microsystems for Bioanalytics, Springer Series on Chemical Sensors and Biosensors (2012) 10: 271–288, DOI 10.1007/978-3-642-25498-7_10, # Springer-Verlag Berlin Heidelberg 2012
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H. Becker and C. G€artner
1 Introduction Just like the microelectronic revolution changed the way how electronic components and circuits were manufactured 50 years ago, which led to an explosive growth in the applications of integrated circuits and a birth of new industries, a similar
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