Posterior pole retinal thickness distribution pattern in keratoconus
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ORIGINAL PAPER
Posterior pole retinal thickness distribution pattern in keratoconus Ali Mahdavi Fard . Sangita P. Patel . Raana Daei Sorkhabi . Sara Salekzamani . Elena Pezzino . Nader D. Nader
Received: 11 January 2020 / Accepted: 2 June 2020 Ó This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020
Abstract Purpose To evaluate the pattern of retinal thickness distribution in patients with keratoconus (KCN) and its correlation with disease severity. Methods For this cross-sectional cohort study, the study subjects with documented keratoconus and normal eyes were prospectively enrolled. All subjects had anterior segment (Pentacam HR) and posterior segment (Spectralis) imaging. Posterior segment imaging by optical coherence tomography included
the posterior pole asymmetry analysis map. Data were analyzed with multiple linear regression models and correlation tests to examine the mean and variance of the measured thickness of the retina and its distribution relative to the presence and severity of KCN. Results A total of 24 subjects with keratoconus (48 eyes) and 14 normal subjects (28 eyes) enrolled in this study. The posterior pole retinal thickness, both superior and inferior hemifields, as well as the overall retinal thickness in KCN patients was greater than the
A. M. Fard S. P. Patel Department of Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA e-mail: [email protected]
Gateway Bldg Suite 550, 77 Goodell Street, Buffalo, NY 14203, USA e-mail: [email protected] E. Pezzino e-mail: [email protected]
S. P. Patel e-mail: [email protected] S. P. Patel Research and Ophthalmology Services, Veterans Administration of Western New York Healthcare System, Buffalo, NY, USA R. D. Sorkhabi S. Salekzamani Department of Ophthalmology, Tabriz university of Medical Sciences, Tabriz, Iran e-mail: [email protected] S. Salekzamani e-mail: [email protected] E. Pezzino N. D. Nader (&) Department of Anesthesiology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, UB-
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control group. There was a direct correlation between the overall retinal thickness of the posterior pole and the severity of KCN (R2 = 0.422, P \ 0.001). However, the variability of the retinal thickness showed no difference between KCN-afflicted and healthy eyes. Conclusion Although KCN is a disease of the anterior segment of the eye, we found an orderly increase in posterior pole retinal thickness that is correlated with the severity of disease in KCN eyes compared to control. These findings suggest that the retina may maintain some degree of plasticity to respond to the degraded optical system of the eye. Keywords Anterior segment Keratometry Keratoconus Optical coherence tomography Posterior pole retinal thickness
Introduction Keratoconus (KCN) is a non-inflammatory, degenerative disease of the cornea that results i
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