Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery
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ORIGINAL PAPER
Subclinical inner retinal layer thickness changes in the fellow eyes of patients with unilateral central retinal artery occlusion: a pilot study Enver Mirza . Gunsu Deniz Mirza . Refik Oltulu . Selman Belviranli . Hurkan Kerimoglu
Received: 18 April 2020 / Accepted: 20 June 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To investigate microstructural changes in the macular inner retinal layers over time in the fellow eyes of patients with unilateral central retinal artery occlusion (CRAO). Methods Spectral-domain optical coherence tomography scans of 16 patients with CRAO were performed at initial examination (1st day), at 1st month, at 3rd month, at 6th month, and the central macular thickness (CMT) and inner retinal layer thicknesses in the fellow eyes of the patients were compared between each visit. The thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL) were calculated in 9 quadrants according to the definition by the Early Treatment Diabetic Retinopathy Study. Results CMT decreased over a 6-month period, but the difference was insignificant among visits (p = 0.072). Also, there were no significant differences in the thicknesses of RNFL and GCL among visits (p [ 0.05 for all quadrants). But there was thinning in the parafoveal superior and perifoveal superior quadrants of the IPL (p = 0.007, p = 0.01) and in the parafoveal temporal quadrant of the INL
E. Mirza (&) G. D. Mirza R. Oltulu S. Belviranli H. Kerimoglu Meram Faculty of Medicine, Department of Ophthalmology, Necmettin Erbakan University, 42080 Meram, Konya, Turkey e-mail: [email protected]
(p = 0.033) within 6 months of follow-up in the fellow eyes of the patients with CRAO. Conclusion This study demonstrated subclinical alterations of the macular inner retinal layers over time in the fellow eyes of CRAO patients. Keywords Central retinal artery occlusion Macular segmentation Retinal nerve fiber layer Ganglion cell layer Optical coherence tomography
Introduction Sudden, unilateral, and painless vision loss is the clinical manifestation of central retinal artery occlusion (CRAO) which is one of the most important emergencies in ophthalmology [1]. The central retinal artery (CRA) is the branch of the ophthalmic artery which is the first branch of the internal carotid artery (ICA) [2]. CRA supplies blood flow to the inner layers of the retina and to the surface layer of the optic disc [2]. It is known that thromboembolic plaque from the atherosclerotic background is the most frequent cause of CRAO [3]. In the acute stage of CRAO, when the blood flow is interrupted congestion begins first and classic cherry red spot, ischemic retinal whitening appearance reveals in fundus. The severity of retinal ischemia, presence of sparing cilioretinal artery, early or late stage of CRAO affects the clinical findings [4].
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Int Ophthalmol
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