Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperati
- PDF / 940,966 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 82 Downloads / 201 Views
RESEARCH
Open Access
Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer Takuto Miyamura1, Noriho Sakamoto1* , Kaori Ishida2, Tomoyuki Kakugawa1,3, Hirokazu Taniguchi4, Yoshiko Akiyama1, Daisuke Okuno1, Atsuko Hara1, Takashi Kido1, Hiroshi Ishimoto1, Takuro Miyazaki5, Keitaro Matsumoto5, Tomoshi Tsuchiya5, Hiroyuki Yamaguchi1, Taiga Miyazaki1, Yasushi Obase1, Yuji Ishimatsu6, Takeshi Nagayasu5 and Hiroshi Mukae1
Abstract Background: Heat shock protein 47 (HSP47), a collagen-binding protein, has a specific role in the intracellular processing of procollagen production. HSP47 expression is associated with cancer growth and metastasis in several types of cancers. However, none of the studies have assessed whether HSP47 expression is associated with the risk of postoperative recurrence of lung cancer until now. Therefore, we aimed to assess this association. Methods: The study population consisted of a cohort of consecutive patients who underwent surgery for lung cancer at Nagasaki University Hospital, Nagasaki, Japan, from January 2009 to December 2010. Patient characteristics, survival and disease-free survival (DFS), and laboratory findings were compared between patients who tested positive and negative for HSP47 expression in lung cancer cells and between those who showed high and low numbers of HSP47-positive fibroblasts in cancer stroma. Results: A total of 133 patients underwent surgery for lung cancer. Sixty-seven patients (50.4%) had HSP47-positive cancer cells, and 91 patients (68.4%) had a higher number of HSP47-positive fibroblasts. The patients with a high number of HSP47-positive fibroblasts had a shorter DFS than those with a low number of HSP47-positive fibroblasts. Multivariate analysis identified only the presence of a high number of HSP47-positive fibroblasts as an independent risk factor for recurrence of lung cancer after surgery (odds ratio, 4.371; 95% confidence interval, 1.054–29.83; P = 0.042). Conclusion: The present study demonstrated that the presence of a high number of HSP47-positive fibroblasts in the cancer stroma was a risk factor for recurrence of lung cancer after surgery. Keywords: Lung cancer, Molecular biology, Pathology, Pulmonary fibrosis, Thoracic surgery
* Correspondence: [email protected] 1 Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's C
Data Loading...
