X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chin
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RESEARCH ARTICLE
X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population Tao Wu & Yun-hua Xu & Xiao-lei Ye
Received: 22 March 2013 / Accepted: 16 April 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013
Abstract There were many studies performed to assess the association between X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and lung cancer risk in Chinese Han population, but contradictory results were reported. To provide a comprehensive and objective assessment of the association, a meta-analysis of all eligible case– control studies was carried out. After searching the databases and reading the abstracts, 12 case–control studies on the association between XRCC1 Arg194Trp polymorphism and lung cancer risk were finally included into this meta-analysis. Those 12 studies included a total of 4,385 cases and 4,545 controls. XRCC1 Arg194Trp polymorphism was associated with increased risk of lung cancer in Chinese Han population under three main models (allele contrast model, odds ratio (OR) = 1.12, 95 % confidence interval (CI) 1.00–1.26, P=0.049; homozygote model, OR = 1.27, 95 % CI 1.09–1.48, P=0.003; recessive model, OR = 1.26, 95 % CI 1.09–1.46, P=0.003). However, there was no obvious association between XRCC1 Arg194Trp polymorphism and lung cancer risk under the dominant model (OR = 1.06, 95 % CI 0.98–1.16, P=0.146). Sensitivity analysis suggested the stability and liability of this meta-analysis. Therefore, this meta-analysis suggests that
T. Wu (*) Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qing-Chun Road, Hangzhou 310003, People’s Republic of China e-mail: [email protected] Y.-h. Xu Shanghai Lung Tumor Clinic Medical Center, Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China X.-l. Ye Ningbo Institute of Medical Sciences, Ningbo 315020 Zhejiang Province, China
XRCC1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population. Keywords XRCC1 Arg194Trp . Lung cancer . Chinese Han population . Meta-analysis
Introduction Lung cancer is the leading cause of cancer deaths worldwide [1, 2]. It is estimated that China will have the highest prevalence of lung cancer in the world with the mortality rate exceeding one million by 2025 [3]. Though there are a large number of studies on lung cancer, the mechanism of lung carcinogenesis is still not fully understood [1]. Previous studies have suggested that smoking and exposure to radiation are risk factors of lung cancer. However, not all subjects exposing to those risk factors develop lung cancer, which suggests that genetic factors also play important roles in the lung carcinogenesis [4]. There is no doubt that cancer can be initiated by DNA damage which can result in errors during DNA synthesis, and individuals with an inherited impairment in the DNA repair capability often suffer from increased ri
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