Prevention of contamination by biopsy needle track contamination using a novel adriamycin-loaded gelatin sponge
- PDF / 315,299 Bytes
- 5 Pages / 595.28 x 793.7 pts Page_size
- 113 Downloads / 168 Views
WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Prevention of contamination by biopsy needle track contamination using a novel adriamycinloaded gelatin sponge Zhen-Feng Li, Jian-Min Li*, Jun Yan, Zhi-Ping Yang, Xin Li and Qiang Yang
Abstract Background: The gold standard of tumor diagnosis is histological examination of a biopsy; however, there is concern that tumor cell dissemination along the needle track during percutaneous biopsy can cause local tumor relapse. We aimed to evaluate the value of an adriamycin (ADM)-loaded gelatin sponge in preventing tumor cell contamination along the biopsy needle track. Methods: Data were obtained from 40 patients who were diagnosed by core needle biopsy as having osteosarcoma and who were followed up at our hospital between 2008 and 2011. Of the 40 patients, 20 had the needle biopsy tracks filled with ADM-loaded absorbable gelatin sponge immediately after the biopsy specimen was obtained, while the other 20 did not. All 40 patients underwent limb-salvage surgery, and specimens were obtained from the biopsy track for histopathologic examination of multiple sections. Results: On histological examination, there was less tumor cell contamination along the biopsy tracks in the ADM group. Conclusion: Use of ADM-loaded absorbable gelatin sponge may prevent tumor cell contamination of a biopsy track, and reduce the possibility of consequent tumor relapse. Keywords: Adriamycin, Gelatin sponge, Biopsy track, Embolism, Osteosarcoma
Background The gold standard of tumor diagnosis is histological examination of a biopsy. Core needle biopsy is becoming the main method of obtaining a sample for pathologic examination for diagnosis of osteosarcoma; however, there is concern that tumor cell dissemination along the needle track during percutaneous might cause local tumor relapse. A few recent reports indicated that tumor cell contamination [1] and local metastasis [2-4] did occur along the needle puncture track. To decrease the likelihood of tumor cell contamination along the track during core needle biopsy, we designed a novel adriamycin (ADM) loaded gelatin sponge and use this to embolize the biopsy needle track. Specimens from the biopsy track were later obtained, and the pathologic results were evaluated and compared with the specimens * Correspondence: [email protected] From the Department of Orthopaedics, Qilu Hospital of Shandong University, 107 Wenhuaxilu, Jinan, Shandong Province 250012, China
of biopsy track. The histological examination showed that there was less tumor cell contamination along the biopsy tracks in the ADM-treated group.
Methods During the period 2008 to 2011, 40 patients with suspected osteosarcoma underwent core needle biopsy. Before biopsy, the 40 patients were randomly divided using a digital table into the ADM (experimental) and non-ADM (control) groups, with equal numbers of patients in each. Details of the clinical data of both groups are illustrated in Table 1. We used a homemade spring-loaded cutting needle to perform the biopsy (Figure 1). This un
Data Loading...
