Primary adenocarcinoma of the rete testis with elevated serum CA19-9 antigen levels
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CASE REPORT
Primary adenocarcinoma of the rete testis with elevated serum CA19‑9 antigen levels Hiroyuki Kitano1 · Kazuhiro Sentani2 · Keisuke Goto1 · Yohei Sekino1 · Ryoken Yamanaka1 · Keiji Nagasaka1 · Yoshinori Shigematsu3 · Kanao Kobayashi3 · Tetsutaro Hayashi1 · Wataru Yasui2 · Jun Teishima1 Received: 2 June 2020 / Accepted: 17 July 2020 © The Japan Society of Clinical Oncology 2020
Abstract Primary adenocarcinoma of the rete testis is an extremely rare tumor with a poor prognosis. Herein, we report a case of primary adenocarcinoma of the rete testis accompanied by elevated serum carbohydrate antigen 19-9 (CA19-9) antigen levels in a 44-year-old man who presented with left scrotal swelling. Para-aortic lymph node swelling was observed on the computed tomography scan. Germ cell tumor markers were within the normal range, but serum CA19-9 antigen levels were high. Radical orchiectomy was performed, and histological examination revealed primary adenocarcinoma of the rete testis with no evidence of other primary carcinomas. The patient underwent three lines of chemotherapy, although no reports suggest the use of gemcitabine and oxaliplatin (GEMOX) in a patient with adenocarcinoma of the rete testis. Unfortunately, he developed metastasis at multiple sites and passed away due to adenocarcinoma 13 months after undergoing orchiectomy. Some reports suggest that CA19-9 antigen levels are elevated in patients with adenocarcinoma of the rete testis, although it has not been clarified whether elevated CA19-9 antigen levels reflect the progression of adenocarcinoma of the rete testis. In this case, as CA19-9 antigen levels increased with progression, CA19-9 might be a marker for primary adenocarcinoma of the rete testis. GEMOX chemotherapy as a line of treatment in primary adenocarcinoma of the rete testis has not been reported. Therefore, further studies must evaluate the efficacy of the aforementioned chemotherapy regimen. Keywords Rete testis · Adenocarcinoma · Carbohydrate antigen 19-9 · Orchiectomy · Combined chemotherapy
Introduction Primary adenocarcinoma of the rete testis is an extremely rare malignant tumor with a poor prognosis. This malignant tumor was first reported in 1945 [1], and approximately 100 cases have been reported worldwide [2,3]. Therefore, standard treatment has not been established. Here, we report a case of adenocarcinoma of the rete testis accompanied by elevated serum carbohydrate antigen 19-9 (CA19-9) antigen * Hiroyuki Kitano tanokin@hiroshima‑u.ac.jp 1
Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1‑2‑3 Minamiku, Hiroshima City, Hiroshima 734‑8551, Japan
2
Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
3
Department of Urology, Chugoku Rosai Hospital, Kure City, Japan
levels and summarize the clinical features and outcomes of such tumors based on our case and a review of the existing literature.
Case report A 44-year-old man with complai
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