Proceedings of the 26th European Paediatric Rheumatology Congress (PReS 2020) - Late Breaking Abstracts
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MEETING ABSTRACTS
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Proceedings of the 26th European Paediatric Rheumatology Congress (PReS 2020) - Late Breaking Abstracts Virtual. 23 - 25 September 2020 Published: 10 December 2020
LB001 Pediatric Systemic Multi-Inflammatory Diseases in Italy During Sars-Cov-2 Epidemic: From Kawasaki Disease To Kawacovid M. Cattalini1, S. Della Paolera2, F. Zunica1, C. Bracaglia3, M. Giangreco4, L. Verdoni5, A. Meini6, R. Sottile7, R. Caorsi8, G. Zuccotti9, M. Fabi10, D. Montin11, A. Meneghel12, A. Consolaro13, R. M. Delle Piane14, M. C. Maggio15, F. La Torre16, A. Marchesi17, G. Simonini18, A. Villani17, R. Cimaz19, A. Ravelli13, A. Taddio4 1 PEDIATRICS CLINIC, UNIVERSITY OF BRESCIA, Brescia; 2University of Trieste, Trieste; 3Bambino Gesù Children's Hospital, Rome; 4IRCCS “Burlo Garofolo”, Trieste; 5 Hospital Papa Giovanni XXIII, Bregamo; 6Pediatrics Clinic University of Brescia , Brescia; 7Santobono-Pausilipon Children's Hospital, Naples; 8IRCCS Istituto Giannina Gaslini, Genova; 9Children's Hospital V Buzzi, Milan; 10IRCCS S. Orsola-Malpighi , Bologna; 11 Department of Pediatrics and Public Health, University of Turin, Turin; 12 University of Padova, Padua; 13IRCCS Istituto Giannina Gaslini, Genoa; 14 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan; 15 University of Palermo, Palermo; 16"Giovanni XXIII", Pediatric Hospital, Bari, Bari; 17Bambino Gesu' Children's Hospital, Rome; 18AOU Meyer, University of Florence, Florence; 19Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy Correspondence: M. Cattalini Pediatric Rheumatology 2020, 18(Suppl 3):LB001 Introduction: Italy was affected by the SARS-CoV-2 epidemic after its outbreak in China. With a 4-weeks delay after the peak in adults, we observed an abnormal number of patients with characteristics of a multi-inflammatory disease and similarities with Kawasaki Disease (KD). Others reported similar cases, defined PIMS-TS or MIS-C.1,2 Objectives: To better characterize clinical features and treatment response of PIMS-TS and to explore its relationship with KD. Methods: We conducted an observational, retrospective, multicenter study. On April 24th-2020 the Rheumatology Study Group of the Italian Pediatric Society launched a national online survey, to enroll patients diagnosed with KD or with a multisystem inflammatory disease between February 1st 2020 and May 31st. The population was then divided into two different groups: 1) Classical and incomplete KD, named Kawasaki Disease Group (KDG); 2) KD-like multi-inflammatory syndrome, named KawaCOVID (KCG). An expert panel of pediatric rheumatologists re-analyzed every single patient to ensure appropriate classification. Data were collected with an online database. Results: 149 cases were studied, 96 with KDG and 53 with KCG. The two population significantly differed for clinical characteristics (see
table 1). Lymphopenia, higher CRP levels, elevated Ferritin and Troponin-T characterized KCG such as lower WBC and platelets (all p values
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