Profiling risk factors of micro-invasive carcinoma within oral potentially malignant disorders: a cross-sectional study
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Profiling risk factors of micro-invasive carcinoma within oral potentially malignant disorders: a cross-sectional study Xi Yang 1,2 & Fubo Chen 3 & Xuemin Shen 4 & Chenping Zhang 2 & Wei Liu 2 Received: 26 July 2020 / Accepted: 2 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objectives To investigate the clinicopathological profile and risk factors of micro-invasive carcinoma within oral potentially malignant disorders (OPMD). Methods Micro-invasive carcinomas were identified in a large prospective series of OPMD patients (n = 810) from eastern China. Logistic regression was applied to evaluate odds ratios (OR) with 95% confidence interval (CI) for indicative of malignant risk in general OPMD. Results Leukoplakia (41.4%), lichen planus (28.0%), and lichenoid lesion (23.7%) were the most 3 clinical subtypes of OPMD. A total of 62 (7.7%) micro-invasive carcinomas within OPMD were identified, and 96.8% of micro-invasive carcinoma was found within leukoplakia and erythroplakia. Multivariate regression analysis revealed that the risk of malignant change within OPMD located on lateral/ventral tongue (OR, 15.1; 95% CI, 1.85–122.8; P = 0.011) was higher than other sites. The risk of malignant change within non-homogenous type (OR, 103.3; 95% CI, 13.39–796.7; P < 0.001) was strikingly higher than other subtypes of OPMD, respectively. Intriguingly, the risk of micro-invasive carcinoma diagnosed in current smoker (OR, 3.96; 95% CI, 1.31–12.02; P = 0.015) was higher than non-smoker. Conclusion This large-scale cross-sectional study elucidated the clinical factors and risk assessment of micro-invasive carcinoma within OPMD. Clinical Relevance Non-homogenous lesions located on lateral/ventral tongue might be monitored at closer intervals, and the need for rigorous management to detect malignant changes. Keywords Oral potentially malignant disorders . Oral cancer . Dysplasia . Micro-invasive carcinoma . Leukoplakia Xi Yang and Fubo Chen contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00784-020-03568-y) contains supplementary material, which is available to authorized users. * Wei Liu [email protected] 1
Department of Oral and Maxillofacial-Head and Neck Oncology, Fengcheng Hospital, Fengxian District, Shanghai, China
2
Department of Oral and Maxillofacial-Head and Neck Oncology, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3
Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
4
Department of Oral Mucosal Diseases, College of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Introduction Oral potentially malignant disorders (OPMD), formerly known
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