Prognostic significance of low pre-transplant skeletal muscle mass on survival outcomes in patients undergoing hematopoi
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ORIGINAL ARTICLE
Prognostic significance of low pre‑transplant skeletal muscle mass on survival outcomes in patients undergoing hematopoietic stem cell transplantation Kazuki Sakatoku1 · Ayumu Ito1 · Kinuko Tajima1 · Kyosuke Yamaguchi1 · Masatomo Kuno1 · Noriko Aoki2 · Takashi Tanaka1 · Saiko Kurosawa1 · Yoshihiro Inamoto1 · Sung‑Won Kim1 · Takahiro Fukuda1 Received: 31 July 2019 / Revised: 29 October 2019 / Accepted: 29 October 2019 © Japanese Society of Hematology 2019
Abstract Little is known about the prognostic significance of muscle loss for allogeneic hematopoietic stem cell transplantation (alloHCT). We retrospectively analyzed consecutive patients who received allo-HCT from 2013 to 2015. All patients underwent computed tomography (CT) imaging and bioelectrical impedance analysis (BIA) within 30 days before allo-HCT. Skeletal muscle area (cm2) at the third lumbar vertebra level on CT imaging and skeletal muscle mass (kg) measured by BIA were normalized by height in meters squared (m2) to calculate the skeletal muscle area index (SMI) and skeletal muscle mass index (SMMI). SMI and SMMI were significantly correlated (r = 0.744; P
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