Skeletal Muscle
In this chapter, we review and highlight recent developments regarding the role of store-operated channels (SOC) and stretch-activated channels (SAC) in skeletal muscle, in the context of Duchenne Muscular Dystrophy (DMD). There is a general consensus tha
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Klaus Groschner • Wolfgang F. Graier • Christoph Romanin Editors
Store-operated Ca2+ Entry (SOCE) Pathways Emerging Signaling Concepts in Human (PATHO)Physiology
Editors Klaus Groschner Institute of Biophysics Center for Physiological Medicine Medical University of Graz Graz, Austria
Wolfgang F. Graier Institute of Molecular Biology and Biochemistry Center for Molecular Medicine Medical University of Graz Graz, Austria
Christoph Romanin Institute of Biophysics University of Linz Linz, Austria
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Preface
Because recapitulation of the historic developments within a scientific field usually helps, or may even be required, for understanding current paradigms and concepts, it appears important to begin with a condensed historic overview characterizing a research area, which has gained an impressive amount of attention due to its impact on various aspects of cell biology. During the past decades, the concept of store-operated Ca2+ entry as a pivotal component of cellular signaling in a wide range of biological systems and as a process of particular importance for human pathology has emerged slowly and with several critical milestones being accomplished only after a tedious process of knowledge acquisition. All of this started with the perception of a Ca2+ transport process that appeared initially to be important only for the more or less direct refilling of intracellular storage compartments. Mobilization or, in other words, discharge of Ca2+ from these storage sites had already been recognized as a crucial signaling step for the control of cellular functions, and the mechanism of recharging of these signaling elements had been envisaged as a process similar to the charging of an electrical capacitator by the
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