Lower skeletal muscle index and early complications in patients undergoing radical cystectomy for bladder cancer
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Lower skeletal muscle index and early complications in patients undergoing radical cystectomy for bladder cancer Fangning Wan1,2†, Yao Zhu1,2†, Chengyuan Gu1,2, Xudong Yao1,2, Yijun Shen1,2, Bo Dai1,2, Shilin Zhang1,2, Hailiang Zhang1,2, Jingyi Cheng3 and Dingwei Ye1,2*
Abstract Background: Radical cystectomy (RC) is the standard treatment for patients with muscle-invasive bladder cancer (BC), and it is also a valid option for selected patients with high-risk non-muscle-invasive BC. The purpose of this study was to evaluate the effect on the lower skeletal muscle index (SMI) of short-term postoperative complications of radical cystectomy (RC) in patients with bladder cancer (BC). Methods: A total of 247 patients who received RC for BC and 204 age-matched healthy population-based controls were retrospectively assessed. SMI was measured by preoperative computed tomography scans at the L4 to L5 level. Early complications were graded by Clavien-Dindo classification; severity of grade III or greater was identified as a severe complication. Logistic regression was utilized to determine the relationships between covariables and severe complications. Results: A total of 125 (50.61%)/19 (7.69%) patients exhibited overall/severe complications during the early postoperative period. SMI was strongly associated with gender (P
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