Promising aberrant DNA methylation marker to predict gastric cancer development in individuals with family history and l
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ORIGINAL ARTICLE
Promising aberrant DNA methylation marker to predict gastric cancer development in individuals with family history and long‑term effects of H. pylori eradication on DNA methylation Hee Jin Kim1,2 · Nayoung Kim1,3,4 · Hyoung Woo Kim5 · Ji Hyun Park3 · Cheol Min Shin1 · Dong Ho Lee1,3,4 Received: 8 June 2020 / Accepted: 23 August 2020 © The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2020
Abstract Objective It remains unknown whether individuals with a family history (FH) of gastric cancer (GC) are associated with aberrant DNA methylation. The aim of this study was to investigate the association between aberrant DNA methylation and FH of GC. Design Using quantitative MethyLight assay, MOS, miR124a-3, NKX6-1, EMX1, CDH1, and TWIST1 methylation levels in the noncancerous gastric mucosa was compared between subjects with and without FH based on GC and Helicobacter pylori (Hp) infection. Changes in the methylation levels were evaluated over time after Hp eradication. Results In Hp-positive GC patients, MOS (P
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