Protein Metabolism and Homeostasis in Aging

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism a

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ADVA V NCES IN EXPERIMENTA T L MEDICINE AND BIOLOGY Editorial Board: NATHAN A BACK, State University of New York at Buffalo IRUN U R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan

Recent Volumes in this Series Volume 686 RARE DISEASES EPIDEMIOLOGY Edited by Manuel Posada de la Paz and Stephen C. Groft Volume 687 BCL-2 PROTEIN FAMILY: ESSENTIAL REGULATORS OF CELL DEATH Edited by Claudio Hetz Volume 688 SPHINGOLIPIDS AS SIGNALING AND REGULATORY MOLECULES Edited by Charles Chalfant and Maurizio Del Poeta Volume 689 HOX GENES: STUDIES FROM THE 20TH TO THE 21ST CENTURY Edited by Jean S. Deutsch Volume 690 THE RENIN-ANGIOTENSIN SYSTEM: CURRENT RESEARCH PROGRESS IN THE PANCREAS Edited by Po Sing Leung Volume 691 ADVANCES IN TNF FAMILY RESEARCH Edited by David Wallach Volume 692 NEUROPEPTIDE SYSTEMS AS TARGETS FOR PARASITE AND PEST CONTROL Edited by Timothy G. Geary and Aaron G. Maule Volume 693 POST-TRANSCRIPTIONAL REGULATION BY STAR PROTEINS Edited by Talila Volk and Karen Artzt Volume 694 PROTEIN METABOLISM AND HOMEOSTASIS IN AGING Edited by Nektarios Tavernarakis

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Protein Metabolism and Homeostasis in Aging Edited by Nektarios T Tavernarakis, PhD Institute of Molecular Biology and Biotechnology (IMBB) Foundation for Research and Technology Hellas (FORTH) Heraklion, Crete, Greece

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Springer Science+Business Media, LLC Landes Bioscience Copyright ©2010 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission                     being entered and executed on a computer system; for exclusive use by the Purchaser of the work. Printed in the USA. Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA http://www.springer.com Please address all inquiries to the publishers: Landes Bioscience, 1002 West Avenue, A Austin, T Texas 78701, USA Phone: 512/ 637 6050; FAX: 512/ 637 6079 http://www.landesbioscience.com The chapters in this book are available in the Madame Curie Bioscience Database. http://www.landesbioscience.com/curie Protein Metabolism and Homeostasis in Aging, edited by Nektarios Tavernarakis. T Landes Bioscience / Springer Science+Business Media, LLC dual imprint / Springer series: Advances in Experimental Medicine and Biology. ISBN: 978-1-4419-7001-5