Protein-Protein Interactions Methods and Applications
In recent years, our understanding of the protein-protein interaction landscape has expanded significantly. Growing interest in analyzing and targeting protein-protein interactions has resulted in an increased need for detailed methodologies to interrogat
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Cheryl L. Meyerkord Haian Fu Editors
Protein-Protein Interactions Methods and Applications Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Protein-Protein Interactions Methods and Applications Second Edition
Edited by
Cheryl L. Meyerkord Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA, USA
Haian Fu Department of Pharmacology, Department of Hematology & Medical Oncology, and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA, USA
Editors Cheryl L. Meyerkord Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine Atlanta, GA, USA
Haian Fu Department of Pharmacology Department of Hematology & Medical Oncology, and Emory Chemical Biology Discovery Center, Emory University School of Medicine Atlanta, GA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2424-0 ISBN 978-1-4939-2425-7 (eBook) DOI 10.1007/978-1-4939-2425-7 Library of Congress Control Number: 2015933374 Springer New York Heidelberg Dordrecht London # Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface From regulation of DNA replication, RNA transcription, and protein translation to posttranslational modifications and signal transduction, protein-protein interactions are critical for most biological functions. In recent years, our understanding of the protein-protein interaction landscape has significantly increased due to advances in genomics, proteomics, and functional and network biology. It is also reco
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