12.18 Correlation between Ambulatory Arterial Stiffness Index (AASI) and Pulse Wave Velocity in a General Population: th
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Vessels and Endothelium 12.18 Correlation between Ambulatory Arterial Stiffness Index (AASI) and Pulse Wave Velocity in a General Population: the Vobarno Study A. Paini (1), M. Salvetti (1), C. Aggiusti (1), E. Belotti (1), G. Galbassini (1), C. Corbellini (1), C. Agabiti-Rosei (1), L. Micheletti (1), F. Bertacchini (1), F. Marino (1), M.L. Muiesan (1), E. Agabiti-Rosei (1) ` di Brescia, Brescia, Italy (1)Universita Introduction. The measurement of Ambulatory Arterial Stiffness Index (AASI) as a marker of arterial compliance and its relation with target organ damage (TOD) are still controversial. Aim. To assess the relationship between AASI, pulse wave velocity (PWV), and other markers of TOD in a general population. Methods. The study included 263 untreated subjects (age 54±9 years, 46% males, 47% hypertensive patients). In all subjects, laboratory examinations and measurement of PWV, left ventricular mass index (LVMI), carotid intima-media thickness (IMT), clinic and 24 hours BP were performed. From individual 24-h recordings the regression slope of diastolic on systolic BP values was computed; AASI was calculated as 1 minus the regression slope. Results. No difference in AASI was observed between normotensive subjects and hypertensive patients (0.35±0.13 vs 0.37± 0.14, p ns), while PWV was significantly greater in hypertensive patients (12.1±3.0 vs 10.1±1.5 m/s, p
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