12.8 Endotelin-1 and 8-Isoprostanes Predict Estimated Glomerular Filtration Rate in Arterial Hypertension
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Vessels and Endothelium 12.8 Endotelin-1 and 8-Isoprostanes Predict Estimated Glomerular Filtration Rate in Arterial Hypertension S. Cottone (1), M. Guarneri (1), G. Mule` (2), R. Riccobene (2), MC. Lorito (2), E. Nardi (2), R. Arsena (1), A. Palermo (2), P. Cusimano (2), F. Vaccaro (1), ` (1), G. Cerasola (2) F. Tornese (1), C. Canale (1), A. Vadala (1)Cattedra di Nefrologia, Dipartimento di Medicina Interna, Malattie ` di Palermo, Palermo; (2)Cattedra di Cardiovascolari e Nefrourologia, Universita Medicina Interna, Dipartimento di Medicina Interna, Malattie Cardiovascolari e ` di Palermo, Palermo, Italy Nefrourologia, Universita Introduction. Hypertension and additional non-traditional risk factors can damage the kidney directly and by promoting atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate a large part of the effects of risk factors on the kidney. We hypothesized that in hypertensive patients (HT) oxidative stress, measured by 8-ISO Prostaglandin F2alpha (8-ISO), should raise in parallel with decreasing renal function, and should correlate with estimated glomerular filtration rate (eGFR). Methods. In 626 consecutive HT having renal function ranging from stage 1 to 5, plasma levels of 8-ISO, high sensitivity C-reactive protein (CRP), Transforming Growth Factor-beta (TGF-beta), and endothelin-1(ET-1) were measured. GFR was estimated by Modification of Diet in Renal Disease Study equation. Results. Plasma concentrations of all the studied molecules showed a progressive and significant increase from stage 1 to stage 5. The multiple regression analysis, considering eGFR as dependent variable, showed that in HT plasma levels of 8-ISO (beta -0.361, p
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