220 Simultaneous measurement of three dimensional (3D) left and right ventricular volumes and ejection fraction during d
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Meeting abstract
220 Simultaneous measurement of three dimensional (3D) left and right ventricular volumes and ejection fraction during dobutamine cardiovascular magnetic resonance Sangeeta Mandapaka*, Craig Hamilton, Kim Lane and William G Hundley Address: Wake Forest University, Winston salem, NC, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A81
doi:10.1186/1532-429X-10-S1-A81
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A81 © 2008 Mandapaka et al; licensee BioMed Central Ltd.
Introduction Appropriate displacement of blood volume from the right into the left ventricle via the pulmonary circulation is necessary to maintain forward cardiac output during stress and prevent inappropriate displacement of blood into the lungs by the right ventricle during left ventricular (LV) failure.
Purpose Cardiovascular magnetic resonance (CMR) has been used to quantify LV and right ventricular (RV) volumes, and ejection fraction (EF) simultaneously at rest, but the feasibility of CMR to quantify simultaneous measures of RV and LV volumes and EF throughout the course of cardiovascular stress testing in humans is unknown.
Methods Thirteen healthy subjects (5 women; 42%), without medical conditions and taking no medications, aged 53 + 10 years, underwent 2 CMR studies separated by 4 to 8 weeks in which dobutamine and atropine were infused to achieve 85% of the maximum predicted heart rate response (MPHRR) for age. Images were acquired with a 1.5 T Excite (General Electrical Medical Systems, Milwaukee, Wisconsin) whole body imaging system using a phased array a cardiac surface coil over the chest. Multislice, steady state free precession cine white blood images were acquired spanning the cardiac base to the apex. Image parameters included an 8 mm thick slice, a 2 mm gap, a 45 cm FOV, a 224 × 160 matrix, a 10 msec repeti-
tion time, a 3 msec echo time, a temporal resolution of 20 msec, a 125 Hz/px band-width, and a flip angle of 50 degrees. Two slices were acquired in the multi-slice stack during 10 second periods of breath-holding. RV and LV volumes, and EF were determined using a Simpson's Rule technique in which the endocardial surface was identified at end-diastole and end-systole in each slice and multiplied by the slice thickness and number of slices to determine the volumes for the respective LV and RV cavities.
Results All data are expressed as mean + standard deviation. At rest, low dose dobutamine (7.5 mcg/kg/min), and peak stress, the heart rates, systolic, and diastolic blood pressures for the participants were 65 + 10, 137 + 16, and 83 + 15; 81 + 13, 39 + 18; and 78 + 13; 134 + 13
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