8.4 Circulating Levels of E-Selectin are Inversely Related to Left Ventricular Wall Thickness in Patients on Regular Dia
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Kidney 8.4 Circulating Levels of E-Selectin are Inversely Related to Left Ventricular Wall Thickness in Patients on Regular Dialysis B. Stancanelli (1), A. Cataliotti (1), I. Bellanuova (1), F. Mallamaci (2), G. Tripepi (1), F.A. Benedetto (3), P. Fatuzzo (1), F. Rapisarda (1), D. Leonardis (2), C. Zoccali (2), L.S. Malatino (1) (1)U.O. Universitaria di Medicina Interna, Ragusa; (2)CNR-IBIM U.O. di Nefrologia, Reggio Calabria; (3)U.O. di Cardiologia Ospedali Riuniti, Reggio Calabria, Italy Introduction. In dialysis patients soluble E-selectin (sE-Se), a biomarker of endothelial activation, was reported to be inversely related to the risk of death and cardiovascular events in dialysis patients. By contrast, in the general population sE-Se is directly related to atherogenic diseases and carotid atherosclerosis. Moreover, in dialysis patients there was no relationship between carotid atherosclerosis and sE-Se. No data are so far available on the correlation between sE-Se and cardiac remodelling. Aim. to evaluate the relationship between left ventricular wall thickness and sE-Se in patients with end-stage renal disease (ESRD). Methods. 237 patients (134/103 M/F) on regular dialysis from at least 6 months (200 on haemodialysis, 37 on continuous ambulatory peritoneal dialysis), with no clinical evidence of inflammatory diseases were recruited. In a midweek non-dialysis day, fasting blood sampling for the measurement of sE-Se (ELISA, R&D, UK), haemoglobin, calcium, phosphate, glucose, total cholesterol, C reactive protein, homocysteine, as well as echocardiographic studies were performed in the same session. Results. sE-Se was significantly (P75° percentile (56.8±18.9 g/m2.7 ) as compared to those dialysis patients belonging to other sE-Se quartiles (sE-Se 50°-75° percentile: 64.5±18.9 g/m2.7;
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