A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19
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ORIGINAL ARTICLE
A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society Mehmet Yekta Oncel 1,2 & Ilke Mungan Akın 3 & Mehmet Kenan Kanburoglu 4 & Cuneyt Tayman 5 & Senay Coskun 6 & Fatma Narter 7 & Ilkay Er 8 & Tinatin Gelenava Oncan 9 & Asli Memisoglu 10 & Merih Cetinkaya 11 & Demet Oguz 12 & Omer Erdeve 13 & Esin Koc 14 & on behalf of the Neo-Covid Study Group Received: 13 July 2020 / Revised: 26 July 2020 / Accepted: 31 July 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Limited data are available on pregnant women with COVID-19 and their neonates. We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Pregnant women (n = 125) who had a positive RT-PCR test and their newborns were enrolled. Cesarean section, prematurity, and low-birthweight infant rates were 71.2%, 26.4%, and 12.8%, respectively. Eight of 125 mothers (6.4%) were admitted to an intensive care unit for mechanical ventilation, among whom six died (4.8%). Majority of the newborns (86.4%) were followed in isolation rooms in the NICU. Four of 120 newborns (3.3%) had a positive RT-PCR test result. Although samples taken on the first day were negative, one neonate became positive on the second day and the other two on the fifth day. Sample from deep tracheal aspirate was positive on the first day in an intubated case. Conclusion: COVID-19 in pregnant women has important impacts on perinatal and neonatal outcomes. Maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission, and low rate of breastfeeding show that family support should be a part of the care in the NICU. Trial registration: ClinicalTrials.gov identifier: NCT04401540 The Neo-Covid Study Group Collaborators list have been uploaded in the appendix for publication in PubMed Communicated by Daniele De Luca * Mehmet Yekta Oncel [email protected]
Tinatin Gelenava Oncan [email protected]
Ilke Mungan Akın [email protected]
Asli Memisoglu [email protected]
Mehmet Kenan Kanburoglu [email protected]
Merih Cetinkaya [email protected]
Cuneyt Tayman [email protected]
Demet Oguz [email protected]
Senay Coskun [email protected] Fatma Narter [email protected] Ilkay Er [email protected]
Omer Erdeve [email protected] Esin Koc [email protected] Extended author information available on the last page of the article
Eur J Pediatr
What is Known:
• The common property of previous reports was the conclusions on maternal outcomes, rather than neonatal outcomes. • Published data showed similar outcomes between COVID-19 pregnant women and others. What is New:
• Higher maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission especiall
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