A network map of Interleukin-10 signaling pathway
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A network map of Interleukin-10 signaling pathway Renu Verma 1,2 & Lavanya Balakrishnan 1 & Kusum Sharma 3 & Aafaque Ahmad Khan 1,2 & Jayshree Advani 1,4 & Harsha Gowda 1,12 & Srikanth Prasad Tripathy 5 & Mrutyunjay Suar 2 & Akhilesh Pandey 6,7,8,9 & Sheetal Gandotra 10 & T. S. Keshava Prasad 1,11,12 & Subramanian Shankar 13
Received: 7 July 2015 / Accepted: 24 July 2015 # The International CCN Society 2015
Abstract Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream
signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and
* T. S. Keshava Prasad [email protected]
1
International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore 560 066, India
* Subramanian Shankar [email protected]
2
School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751 024, India
3
Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India
4
Manipal University, Madhav Nagar, Manipal 576 104, India
5
Department of Microbiology, National JALMA Institute for Leprosy & Other Mycobacterial Diseases (Indian Council of Medical Research), Agra 282 004, India
Renu Verma [email protected] Lavanya Balakrishnan [email protected] Kusum Sharma [email protected]
6
Aafaque Ahmad Khan [email protected]
McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, USA
7
Jayshree Advani [email protected]
Departments of Biological Chemistry, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD 21205, USA
8
Departments of Oncology, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD 21205, USA
9
Srikanth Prasad Tripathy [email protected]
Departments of Pathology, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD 21205, USA
10
CSIR-Institute of Genomics and Integrative Biology, New Delhi 110 020, India
Mrutyunjay Suar [email protected]
11
NIMHANS-IOB Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
12
YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore 575018, India
13
Command Hospital (Air Force), Bangalore 560 007, India
Harsha Gowda [email protected]
Akhilesh Pandey [email protected] Sheetal Gandotra [email protected]
R. Verma et al.
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