A review of Korean medicine treatment on febrile convulsion and its possible treatment protocol about Korean medicine co
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REVIEW
A review of Korean medicine treatment on febrile convulsion and its possible treatment protocol about Korean medicine combined with conventional western medicine Hwan Su Jung1 Received: 25 August 2020 / Accepted: 30 August 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract This review aims at summarizing treatment of Korean medicine on febrile convulsion and proposing a possible protocol about Korean medicine combined with conventional western medicine for effective therapies of febrile seizures. Experimental researches on Korean medicine treatment related to febrile seizures or seizures, and clinical studies focusing on pattern identification were searched through Google Scholar, Research Information Sharing Service, Oriental Medicine Advanced Searching Integrated System, National Digital Science Library, Korean studies Information Service System and China National Knowledge Infrastructure. Of 152 articles searched, 20 articles were finally selected. Through various experimental studies, Korean medicine administration was significant in suppressing the occurrence of convulsions. In clinical studies based on pattern identification in China, retention enema with herbal medicine decoction was significantly more effective and had fewer side effects than sedatives. The effects of suppressing the convulsion were recognized experimentally and clinically in some herbal medicine. In the future, combination of Korean medicine with conventional western medicine is necessary for effective treatment of febrile seizure. Keywords Febrile seizure · Korean medicine · Guideline · Suppression of seizure
Introduction Febrile convulsion (FC) is the most common form of seizure manifested in children between 6 months and 5 years of age. FC is characterized by convulsions that occur in association with high fever above 38 °C without any apparent causes, such as infection, head injury, and drug or electrolyte imbalance (Laino et al. 2018; Leung et al. 2018). The prevalence of FC varies across race and region, with peak incidences at 12–18 months of age in the United States and Europe. It has been reported to occur in 2–5% of children aged 6 months to 5 years. The pervasiveness of the condition is higher in the Asia-Pacific region, with 14% cases reported in Guam, 5–10% in India, and 6–9% in Japan (Laino et al. 2018; Leung et al. 2018). Although there * Hwan Su Jung [email protected] 1
Department of Pediatrics, College of Korean Medicine, Sang-Ji University, 80, Sangjidae‑gil, Gangwon‑do, Wongju, Korea
are no statistical data on the prevalence of FC in Korea, it is estimated to be similar to the rates of prevalence in India and Japan (Kwon et al. 2008). FC is considered as an age-dependent reaction in the immature brain upon the incidence of fever (Leung et al. 2018). Since the exact causes of FC are still unknown (Laino et al. 2018; Leung et al. 2018), it is generally classified into simple FC and complicated FC based on its clinical symptoms (Ahn 2012). Owing to its self-limiting characteristic
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