A study of a biodegradable braided Mg stent for biliary reconstruction
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A study of a biodegradable braided Mg stent for biliary reconstruction Yue Zhang1,2, Kaiyuan Chen1,2, Huan Liu3, Yi Shao1,2,4, Chenglin Chu1,2, Feng Xue1,2, and Jing Bai1,2,4,* 1
School of Materials Science and Engineering, Southeast University, Jiangning, Nanjing 211189, Jiangsu, China Jiangsu Key Laboratory for Advanced Metallic Materials, Jiangning, Nanjing 211189, Jiangsu, China 3 College of Mechanics and Materials, Hohai University, Jiangning, Nanjing 211100, China 4 Institute of Biomedical Devices (Suzhou), Southeast University, Suzhou 215163, Jiangsu, China 2
Received: 24 June 2020
ABSTRACT
Accepted: 21 August 2020
Aiming at deficiencies in non-degradable stents for benign common bile duct obstruction, the magnesium (Mg)-based braided stents were developed with one monofilament as a pilot research in this paper. We designed stents with the different monofilament diameter, braided-pin number and surface treatment systematically to study the mechanical and degradation behaviors. The results suggest the fluorinated Mg stents and them with polycaprolactone (PCL) coating can achieve the compression force of 3.35–11.07 N and 11.09–24.08 N, and even maintain 3.10–10.43 N for 3 days immersion and 3.11–9.37 N for 20 days immersion respectively. PCL coating on monofilament can provide significantly better compression force and corrosion resistance. By comparison with the stent in clinic, these Mg stents are expected to meet the demand of the radial compression force and implantation time. Furthermore, the degradation occurs at the ends preferentially for all stents, but for stents without PCL coating, the intersections of wire-mesh are also the area easily corroded. Additionally, the result of the compression test indicates the radial compression force is improved with the increase of monofilament diameter and pins number, but the recovery capability decreases slightly.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Annela M. Seddon.
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https://doi.org/10.1007/s10853-020-05289-9
J Mater Sci
GRAPHIC ABSTRACT
Abbreviations CBD Common bile duct FDA Food and Drug Administration PCL Polycaprolactone Fc Radial compression force Erecovery Elastic recovery ratio
Introduction Common bile duct (CBD) obstruction is a common disease occurring in hepatobiliary surgery, causing the thorniest issue for patients and surgeons. Implanting T tube drainage made of silicone rubber has widely been used to support CBD after removing the CBD stone, but it still has many complications during treatment [1, 2]. With the development of interventional therapy and materials science, various biliary stents are prepared for biliary stricture to prevent stenosis and support the reconstruction. Common materials including nitinol alloy, stainless steel and plastic, are used for biliary stents to guarantee enough supporting force with good bending and compliance properties [3–5]. These stents have good clinical efficacy but needed to be reserved in t
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